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. 2006 Dec 5;27(8):455–458. doi: 10.1002/clc.4960270807

Association of genetic polymorphisms in the fibrinogen and platelet glycoprotein genes with unstable angina in Chinese patients

Ni Yongbin 1, Hu Dayi 1,✉, Yu Hong 1, Li Cuilan 1, Liu Wenling 1, Wang Hongyu 1, Li Lei 1
PMCID: PMC6654742  PMID: 15346842

Abstract

Background: Inherited predisposition has been associated with coronary artery disease (CAD) in the white population.

Hypothesis: The objective of this study was to investigate the association between the risk of unstable angina (UA) and genetic factors believed to be associated with an increased tendency toward thrombosis (the variable number of tandem repeats [VNTR] polymorphism of the platelet glycoprotein [GP] Iba gene, P1A1/A2 of the platelet GP IIIa gene, 448G/A of the Bβ fibrinogen gene and Thr312 A1a of the Act fibrinogen gene) in Chinese patients with UA.

Methods: We performed a case/control study evaluating 69 Chinese patients (43 men, 26 women) with UA and 69 control subjects without CAD, individually matched for age and gender. The restriction fragment length polymorphism (RFLP) method was used to determine the genetic polymorphisms.

Results: The frequencies of GP Ibα C/B genotype and Bβ fibrinogen 448 A allele were higher in patients with UA (46.4 vs. 30.4%, odds ratio [OR] 1.977, 95% confidence interval [CI] 0.98‐3.97, p = 0.054, and 49.3 vs. 20.3%, OR 3.816, 95%CI 1.797‐8.103, p = 0.000, respectively). Only four subjects (two cases, two controls) with GP IIIa PlA2 allele were found, and there was no association between Act fibrinogen Thr312Ala polymorphism and UA.

Conclusions: Chinese patients with UA had increased frequencies of GP Iba C/B genotype and Bβ fibrinogen 448A allele. These data suggest that some genetic factors may influence the development of UA.

Keywords: unstable angina, polymorphism, fibrinogen, platelet glycoprotein

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