Abstract
The treatment of hypertension continues to be challenging due to the lack of understanding regarding underlying modulators of blood pressure as well as co‐existing conditions such as atherosclerosis and diabetes. This has led to uncertainty regarding treatment strategy and intensity. The INternational VErapamil SR/trandolapril STudy (INVEST) is designed to evaluate the relationship between cardiovascular risk and blood pressure modulators. Based on a review of preliminary data, it appears that the treatment regimen used in the INVEST trial has been more successful than other studies at controlling systolic blood pressure (SBP), diastolic blood pressure (DBP), and pulse pressure. These preliminary data from INVEST suggest that a high proportion of coronary artery disease (CAD) patients with hypertension should receive combination therapy to achieve contemporary blood pressure targets.
Keywords: diastolic blood pressure, hypertension, INVEST, pulse pressure, systolic blood pressure
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References
- 1. Swales JD, Current clinical practice in hypertension: The EISBERG (Evaluation and Interventions for Systolic Blood pressure Elevation‐Regional and Global) project. Am Heart J 1999; 138: 231–237 [DOI] [PubMed] [Google Scholar]
- 2. EUROASPIRE I and II Group : Clinical reality of coronary prevention guidelines: A comparison of EUROASPIRE I and II in nine countries. European Action on Secondary Prevention by Intervention to Reduce Events. Lancet 2001; 357: 995–1001 [DOI] [PubMed] [Google Scholar]
- 3. Alderman MH, A new model of risk: Implications of increasing pulse pressure and systolic blood pressure on cardiovascular disease. J Hypertens 1999: 17 (suppl 5): S25–S28 [PubMed] [Google Scholar]
- 4. Schrier RW, Estacio RO, Additional follow‐up from the ABCD trial in patients with type 2 diabetes and hypertension. N Engl J Med 2000: 343: 1969 [DOI] [PubMed] [Google Scholar]
- 5. Hansson L., Zanchetti A., Carruthers SG, Dahlof B., Elmfeldt D., Julius S., Menard J., Rahn KH, Wedel H., Westerling S., Effects of intensive blood‐pressure lowering and low‐dose aspirin in patients with hypertension: Principal results of the Hypertension Optimal Treatment (HOT) randomised trial. HOT Study Group. Lancet 1998; 351: 1755–1762 [DOI] [PubMed] [Google Scholar]
- 6. UK Prospective Diabetes Study (UKPDS) Group : Intensive blood‐glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 1998; 352: 837–853 [PubMed] [Google Scholar]
- 7. Conlin PR, Williams GH, Use of calcium channel blockers in hypertension. Adv Intern Med 1998; 43: 533–562 [PubMed] [Google Scholar]