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. 2009 Feb 3;23(10):776–780. doi: 10.1002/clc.4960231016

Transient increase in plasma brain (b‐type) natriuretic peptide after percutaneous transluminal coronary angioplasty

Jun Tateishi 1,✉, Motomaru Masutani 1, Mitsumasa Ohyanagi 1, Tadaaki Iwasaki 1
PMCID: PMC6655081  PMID: 11061057

Abstract

Background: Brain (B‐type) natriuretic peptide (BNP) is known to be secreted predominantly from the myocardium. Brain natriuretic peptide plasma concentrations have been shown to be markedly increased in patients with acute myocardial infarction; however, plasma BNP response during episodes of myocardial ischemia has not been established.

Hypothesis: This study was designed to examine plasma BNP in patients with transient myocardial ischemia induced by inflation of a percutaneous transluminal coronary angioplasty (PTCA) balloon.

Methods: Thirty consecutive patients (26 men and 4 women; mean age 61 years) who underwent PTCA, and another 49 patients (39 men and 10 women; mean age 63 years) who underwent diagnostic coronary angiography were enrolled in this study. Serum BNP concentrations were assayed in all patients.

Results: Plasma BNP was increased significantly with a peak concentration of 66.1 ± 65.2 pg/ml 24 h after PTCA. Coronary angiography did not cause plasma BNP increase (immediately before 30.4 ± 29.0 pg/ml, 24 h after 33.7 ± 30.6 pg/ml). No significant differences were present in hemodynamic parameters measured immediately before and 24 h after PTCA.

Conclusion: Plasma BNP is increased by transient myocardial ischemia induced by PTCA.

Keywords: brain (B‐type) natriuretic peptide, myocardial ischemia, percutaneous transluminal coronary angioplasty, angina pectoris, coronary angiography

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