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. 2009 Feb 3;22(2):91–94. doi: 10.1002/clc.4960220207

Early mitral regurgitation after acute myocardial infarction does not contribute to subsequent left ventricular remodeling

Aleksandar N Nešković 1,✉, Jelena Marinković 1, Milovan Bonjić 1, Aleksandar D Popović 1
PMCID: PMC6655665  PMID: 10068845

Abstract

Background: It is well known that mitral regurgitation may lead to left ventricular dilation; however, the relationship between progressive left ventricular dilation after acute myocardial infarction (MI) and mitral regurgitation has not yet been clarified.

Hypothesis: This study tested the hypothesis that early mitral regurgitation contributes to left ventricular remodeling after acute MI.

Methods: We prospectively evaluated 131 consecutive patients by serial two‐dimensional and Doppler echocardiography on Days 1,2,3, and 7, after 3 and 6 weeks, 3 and 6 months, and 1 year following acute MI. Patients were divided into two groups: those with mitral regurgitation in the first week after acute MI (Group 1, n = 34) and those without mitral regurgitation (Group 2, n = 81).

Results: Over 1 year, a significant increase in end‐diastolic volume index (from 62.1 ± 12.9 to 70.5 ± 23.6 ml/m2, p = 0.001) with a strong linear trend (F = 15.1, p<0.001) was noted. Initial end‐diastolic volume index was higher in Group 1 (65.6 ± 13.3 vs. 60.4 ± 12.5 ml/m2, p = 0.047), but this difference remained constant throughout the study (F = 1.76, p = NS). Therefore, the pattern of end‐diastolic volume changes was similar in both groups during the period of observation.

Conclusions: These data indicate that early mitral regurgitation after acute MI does not contribute to subsequent left ventricular remodeling in the first year after myocardial infarction.

Keywords: left ventricular remodeling, myocardial infarction, mitral insufficiency

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