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. 2019 Jul 24;14(7):e0220470. doi: 10.1371/journal.pone.0220470

Correction: Machine learning approach yields epigenetic biomarkers of food allergy: A novel 13-gene signature to diagnose clinical reactivity

The PLOS ONE Staff
PMCID: PMC6655739  PMID: 31339952

In the Introduction, there is an error in the third sentence of the third paragraph. The correct sentence is: As a result, food challenges are often under performed, leading to an overdiagnosis of FA [9].

There is an error in Table 6. The vales in column 4 "Average Accuracy" are incorrect. The publisher apologizes for the error. Please see the correct Table 6 here.

Table 6. Average hidden data accuracy across a large number of dataset permutations.

Number Signature n Average Accuracy AUROC 95% CI for Accuracy
1 12-CpG #1 200 95.313 0.98328 (94.175, 96.451)
2 12-CpG #2 200 95.625 0.98531 (94.483, 96.767)
3 18-CpG 200 93.438 0.98047 (92.216, 94.734)

This table shows the average accuracy and AUROC across n randomized hidden test cohorts. The 95% Confidence Interval for accuracy is also shown and provides an estimate for the true population accuracy of each classifier on similar cohorts of patients.

Reference

  • 1.Alag A (2019) Machine learning approach yields epigenetic biomarkers of food allergy: A novel 13-gene signature to diagnose clinical reactivity. PLoS ONE 14(6): e0218253 10.1371/journal.pone.0218253 [DOI] [PMC free article] [PubMed] [Google Scholar]

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