Abstract
The development of a clinically correlated human pericardial fluid bank and database is described. A unique feature of this registry is the availability of a large number of pericardial fluid samples for testing with respect to multiple factors and for correlation with angiographic findings and clinical syndromes expressed by the patients. The collection of data at the present time comprises frozen pericardial fluid samples obtained from patients who have undergone cardiac surgery; and historical, clinical, and laboratory data obtained from the patient records. Nearly 400 samples have been stored and analyzed thus far, with sample entry continuing. This registry is designed to evaluate the local factors that play a role in mediating or reflecting myocardial or coronary responses. Pathophysiologic processes of particular interest include restenosis, plaque ruptures, and angiogenesis. Study of the pericardial fluid bank should lead to enhanced understanding of molecular mechanisms, as well as to the explanation for the reasons underlying interpatient variability in these processes. It is further anticipated that this information might provide a foundation for the diagnostic use of pericardial fluid to individualize therapies targeting angiogenesis or plaque physiology.
Keywords: angiogenesis, cytokines, database, growth factors, pericardial fluid, plaque stability, registry
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References
- 1. Gibson AT, Segal MB: A study of the composition of pericardial fluid, with special reference to the probable mechanisms of fluid formation. J Physiol 1978; 277: 367–377 [DOI] [PMC free article] [PubMed] [Google Scholar]
- 2. Corda S, Mebazaa A, Gandolfini MP, Fitting C, Marotte F, Peynet J, Charlemange D, Cavaillon JM, Payen D, Rappaport L, Samuel JL: Trophic effect of human pericardial fluid on adult cardiac myocytes. Circ Res 1997; 81: 679–687 [DOI] [PubMed] [Google Scholar]
- 3. Fujita M, Ikemoto M, Kishishita M, Otani H, Nohara R, Tanaka T, Tamaki S, Yamazato A, Sasayama S: Elevated basic fibroblast growth factor in pericardial fluid of patients with unstable angina. Circulation 1996. Aug 15; 94 (4): 610–613 [DOI] [PubMed] [Google Scholar]
- 4. Braunwald E: Unstable angina: A classification. Circulation 1989; 80 (2): 410–414 [DOI] [PubMed] [Google Scholar]
- 5. Cortina A, Ambrose JA, Prieto‐Granada J, Moris C, Simarro E, Holt J, Fuster V: Trophic effect of human pericardial fluid on adult cardiac myocytes. Differential role of fibroblast growth factor‐2 and factors related to ventricular hypertrophy. J Am Coll Cardiol 1985; 5: 619–624 3973258 [Google Scholar]
- 6. Horkay F, Szokodi I, Selmeci L, Merkely B, Kekesi V, Vecsey T, Vuolteenaho O, Ruskoaho H, Juhasz‐Nagy A, Toth M: Presence of immunoreactive endothelin‐1 and atrial natriuretic peptide in human pericardial fluid. Life Sci 1998; 62 (3): 267–274 [DOI] [PubMed] [Google Scholar]
- 7. Amano J, Suzuki A, Sunamori M, Shichiri M, Marumo F: Atrial natriuretic peptide in the pericardial fluid of patients with heart disease. Clin Sci 1993; 85: 165–168 [DOI] [PubMed] [Google Scholar]
- 8. Klemda R, Laine M, Weckstrom M, Vuolteenaho O, Ruskoaho H, Huttunen P, Leppaluoto J: High concentrations of atrial natriuretic‐peptide and brain natriuretic peptide in rat pericardial fluid and their reduction by reserpine in vivo. Naunyn Schmiedebergs Arch Pharmacol 1995; Sept, 352 (3): 331–336 [DOI] [PubMed] [Google Scholar]