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. 2009 Feb 3;20(Suppl 1):3–6. doi: 10.1002/clc.4960201303

The emerging role of contrast agents in echocardiography

Anthony N Demaria 1,2
PMCID: PMC6655799  PMID: 9383595

Abstract

Because of an outstanding track record for diagnostic accuracy, noninvasive properties, ease of use, and relatively low expense, echocardiography has become a leading technique in the evaluation of cardiac disorders. In the three decades since echocardiography entered the ranks of standard cardiac diagnostic tools, refinements and technological advances have progressively increased its usefulness. One of the most noteworthy advancements has been the development of ultrasound contrast agents, which investigators are avidly seeking to apply to a broad spectrum of clinical settings and issues.

Keywords: contrast agents, echocardiography, effectiveness, development, microbubble, applications

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References

  • 1. Correas J‐M, Kessler D, Worah D, Quay S: The first phase shift ultrasound contrast agent: EchoGen In Ultrasound Contrast Agents (Ed. Goldberg BB.), p. 101–120. London: Martin Dunitz, 1997. [Google Scholar]
  • 2. De Jong N, Ten Cate FJ: New ultrasound contrast agents and technological innovations. Ultrasonics 1996; 34: 587–590 [DOI] [PubMed] [Google Scholar]
  • 3. Villarraga HR, Foley DA, Mulvagh SL: Contrast echocardiography 1996: A review. Tex Heart Inst J 1996; 23: 90–97 [PMC free article] [PubMed] [Google Scholar]
  • 4. Villanueva FS, Kaul S: Assessment of myocardial perfusion in coronary artery disease using myocardial contrast echocardiography. Coron Art Dis 1995; 6: 18–28 [DOI] [PubMed] [Google Scholar]
  • 5. Aronson S, Han LK: Stress echocardiography, contrast echocardiography, and tissue characterization: Applications for the future. Crit Care Clin 1996; 12: 429–450 [DOI] [PubMed] [Google Scholar]
  • 6. Falcone RA, Marcovitz PA, Perez JE, Dittrich HC, Hopkins WE, Armstrong WF: Intravenous Albunex during dobutamine stress echocardiography: Enhanced localization of left ventricular endocardial borders. Am Heart J 1995; 130: 254–258 [DOI] [PubMed] [Google Scholar]
  • 7. Ge J, Erbel R: Novel techniques of coronary artery imaging. Curr Opin Cardiol 1995; 10: 626–633 [DOI] [PubMed] [Google Scholar]
  • 8. Firschke C, Lindner JR, Goodman NC, Skyba DM, Wei K, Kaul S: Myocardial contrast echocardiography in acute myocardial infarction using aortic root injections of microbubbles in conjunction with harmonic imaging: Potential application in the cardiac catheterization laboratory. J Am Coll Cardiol (as per 1997 Index Medicus ) 1997; 29: 207–216 [DOI] [PubMed] [Google Scholar]
  • 9. Cotter B, Kriett J, Perricone T, Kwan OL, Cha Y, Nozaki S, Calisi C, DeMaria AN: Detection of coronary artery occlusion by decreased myocardial opacification following intravenous injection of QW3600 (EchoGenTM). Presented at the 67th Scientific Sessions, American Heart Association, Dallas, Texas, November 14–17,1994.
  • 10. Nanto S, Masuyama T, Lim Y‐J, Hori M, Kodama K, Kamada T: Demonstration of functional border zone with myocardial contrast echocardiography in human hearts: Simultaneous analysis of myocardial perfusion and wall motion abnormalities. Circulation 1993; 88: 447–453 [DOI] [PubMed] [Google Scholar]
  • 11. Cheirif J: Diagnosis of myocardial stunning: A new use for myocardial contrast and dobutamine echocardiography. Am J Cardiol Imag 1995; 9: 261–268 [PubMed] [Google Scholar]
  • 12. Beppu S, Matsuda H, Shishido T, Miyatake K: Success of myocardial contrast echocardiography by peripheral venous injection method: Visualization of area at risk. Circulation 1993; 88 (suppl): 1–401 [Google Scholar]
  • 13. Grayburn PA, Erikson JM, Velasco CE: Assessment of myocardial risk area and infarct size using peripheral injection of a new phase shift echo contrast agent. Presented at the 67th Scientific Sessions, American Heart Association, Dallas, Texas, November 14–17,1994.
  • 14. Villanueva FS, Camarano G, Ismail S, Goodman NC, Sklenar J, Kaul S: Coronary reserve abnormalities in the infarcted myocardium: Assessment of myocardial viability immediately versus late after reflow by contrast echocardiography. Circulation 1996; 94: 748–754 [DOI] [PubMed] [Google Scholar]
  • 15. Hirata N, Shimazaki Y, Nakano S, Sakai K, Sakaki S, Matsuda H: Evaluation of regional myocardial perfusion in areas of old myocardial infarction after revascularization by means of intraoperative myocardial contrast echocardiography. J Thorac Cardiovasc Surg 1994; 108: 1119–1124 [PubMed] [Google Scholar]
  • 16. Melany ML, Grant EG: Clinical experience with sonographic contrast agents. Semin Ultrasound CT MRI 1997; 18: 3–12 [DOI] [PubMed] [Google Scholar]
  • 17. Ishii M, Kato H, Inoue O, Takagi J, Akagi T, Miyake T, Sugimura T, Maeno Y, Hashino K, Kawano T: Noninvasive evaluation of systolic pressures of pulmonary artery and right ventricle using contrast‐enhanced Doppler echocardiography: Comparative study using sonicated albumin or glucose solution. Pediatr Cardiol 1996; 17: 175–180 [DOI] [PubMed] [Google Scholar]
  • 18. von Bibra H, Sutherland G, Becher H, Neudert J, Nihoyannopoulos P, for the Levovist Cardiac Working Group : Clinical evaluation of left heart Doppler contrast enhancement by a saccharide‐based transpulmonary contrast agent. J Am Coll Cardiol 1995; 25: 500–508 [DOI] [PubMed] [Google Scholar]
  • 19. Cao Q‐L, Masani N, Delabays A, Magni G, Acar P, Laskari C, Yao J, De Castro S, Pandian N: Harmonic imaging and single frame “triggered mode” data acquisition enhance delineation of myocardial perfusion defects by volume‐rendered 3‐dimensional echocardiography. Presented at the American College of Cardiology, Orlando, Florida, March 24–27,1996.
  • 20. Marber MS, de Belder MA, Pumphrey CW, Leech G, Camm AJ: Transoesophageal echocardiography in the diagnosis of paradoxical embolism. Int J Cardiol 1992; 34: 283–288 [DOI] [PubMed] [Google Scholar]
  • 21. Dick AE, Gross CM, Rubin JW: Echocardiographic detection of an infected superior vena caval thrombus presenting as a right atrial mass. Chest 1989; 96: 212–214 [DOI] [PubMed] [Google Scholar]
  • 22. Skorton DJ, Vandenberg BF: Cardiac ultrasound: Progress and prospects. Invest Radiol 1993; 28 (suppl 4): S19–S25 [PubMed] [Google Scholar]
  • 23. Gramiak R: The beginnings of ultrasound contrast In Ultrasound Contrast Agents (Ed. Goldberg BB.), p. 1–7. London: Martin Dunitz, 1997. [Google Scholar]
  • 24. Plummer D: Principles of emergency ultrasound and echocardiography. Ann Emerg Med 1989; 18: 1291–1297 [DOI] [PubMed] [Google Scholar]
  • 25. Needleman L, Robbin ML, Beach KW, Platt JF, Merritt CB, Arger PH: Phase II clinical trial of a new perfluorochemical emulsion US contrast agent. Presented at the Radiological Society of North America, Chicago, Illinois, November 26–December 1, 1995.
  • 26. Tokgözoglu SL, Caner B, Kabakci G, Kes S: Measurement of right ventricular ejection fraction by contrast echocardiography. Int J Cardiol 1997; 59: 71–74 [DOI] [PubMed] [Google Scholar]
  • 27. Belohlavek M, Foley DA, Gerber TC, Kinter TM, Greenleaf JF, Seward JB: Three‐ and four‐dimensional cardiovascular ultrasound imaging: A new era for echocardiography. Mayo Clin Proc 1993; 68: 221–240 [DOI] [PubMed] [Google Scholar]
  • 28. Correas J‐M, Quay SC: EchoGenTM emulsion: A new ultrasound contrast agent based on phase shift colloids. Clin Radiol 1996; 51 (suppl 1): 11–14 [PubMed] [Google Scholar]
  • 29. Sheil MLK, Kaul S, Spotnitz WD: Myocardial contrast echocardiography: Development, applications, and future directions. Acad Radiol 1996; 3: 260–275 [DOI] [PubMed] [Google Scholar]
  • 30. Angermann CE, Krüger TM, Junge R, Drewello R, Stempfle HU, Spes CH, Theisen K: Intravenous Albunex during transesophageal echocardiography: Quantitative assessment by videodensitometry and integrated backscatter analysis from unprocessed radiofrequency signals. J Am Soc Echocardiogr 1995; 8: 839–853 [DOI] [PubMed] [Google Scholar]
  • 31. Pandian NG, Schwartz SL, Weintraub AR, Hsu TL, Konstam MA, Salem DN: Intracardiac echocardiography: Current developments. Int J Card Imaging 1991; 6: 207–219 [DOI] [PubMed] [Google Scholar]
  • 32. Glazier JJ, Herregods MC, Verwilghen J, De Geest H, Piessens J: Clinical applications of echocardiography in patients with acute myocardial infarction. Ir Med J 1993; 86: 68–71 [PubMed] [Google Scholar]
  • 33. Wilansky S: Update on cardiovascular imaging: Echocardiography. Tex Heart Inst J 1996; 23: 88–89 [PMC free article] [PubMed] [Google Scholar]
  • 34. Mizushige K, DeMaria AN, Toyama Y, Morita H, Senda S, Matsuo H: Contrast echocardiography for evaluation of left ventricular flow dynamics using densitometric analysis. Circulation 1993; 88: 588–595 [DOI] [PubMed] [Google Scholar]
  • 35. Marmion M, Deutsch E: Tracers and contrast agents in cardiovascular imaging: Present and future. J Nucl Biol Med 1996; 40: 121–131 [PubMed] [Google Scholar]
  • 36. Feigenbaum H: Evolution of echocardiography. Circulation 1996; 93: 1321–1327 [DOI] [PubMed] [Google Scholar]

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