Table 5.

Twenty-Four Genes Downregulated Represented in Islets From 15-Wk-Old GDM Offspring Compared With Lean Offspring

Gene Symbol	Gene Name	GDM-HFS
Cd69	CD69 molecule	−2.7
Ptgs2	Prostaglandin-endoperoxide synthase 2	−2.3
Tf	Transferrin	−2.1
Ccr7	C-C motif chemokine receptor 7	−4.0
Itm2a	Integral membrane protein 2A	−2.8
Cp	Ceruloplasmin	−2.0
Cxcl2	C-X-C motif chemokine	−2.6
Csf1	Colony stimulating factor 1	−1.9
Igfbp5	Insulin-like growth factor binding protein 5	−1.9
Gja1	Gap junction protein, alpha 1	−2.0
Ptx3	Pentraxin 3	−4.4
C3	Complement C3	−2.9
Cfb	Complement factor B	−2.6
Fmod	Fibromodulin	−6.1
Il6	Interleukin 6	−2.3
Lcn2	Lipocalin 2	−2.5
Ifit3	Interferon-induced protein with tetratricopeptide repeats 3	−2.4
Slfn4	Schlafen 4	−3.6
Ngf	Nerve growth factor	−1.5
Tnfaip2	TNF alpha induced protein 2	−2.5
Ifitm3	Interferon induced transmembrane protein 3	−1.7
Il1a	Interleukin 1 alpha	−3.9
Icam1	Intercellular adhesion molecule 1	−1.7
C1s	Complement C1s	−1.7

Data are log₂ fold change. Fold cutoff (−1.5-fold or fewer changes or 1.5-fold or more changes), FDR of ≤0.05.