Figure 1:

Time on study treatment (days) for patients evaluable for response. Light blue: dose level 1, medium blue: dose level 2, dark blue: dose level 3, gray: expansion cohort. Each bar is denoted with subject’s best response; SD: stable disease, PD: progressive disease. *denotes patient who discontinued treatment due to possible treatment-related toxicity after response evaluation, **denotes patient who discontinued due to clinical progression