Table 2.
Intrinsic properties of FG-labeled dural afferent neurons from adult WT and TRESK KO mice
| Diameter, μm | Capacitance, pF | Rin, MΩ | Vrest, mV | Rheobase, pA | AP threshold, mV | AP amplitude, mV | AP half-width, ms | AHP amplitude, mV | Cell number | |
|---|---|---|---|---|---|---|---|---|---|---|
| Small IB4-negative dural afferent neurons | ||||||||||
| WT | 19.2 ± 0.5 | 20.9 ± 1.1 | 586 ± 84 | −55.6 ± 1.2 | 73 ± 9 | −16.7 ± 1.6 | 113.0 ± 2.7 | 3.3 ± 0.4 | −16.9 ± 1.3 | 15 |
| KO | 18.2 ± 1.3 | 20.3 ± 1.1 | 1058 ± 60*** | −55.5 ± 1.6 | 38 ± 4*** | −14.6 ± 1.1 | 111.5 ± 1.7 | 4.0 ± 0.3 | −18.6 ± 1.4 | 20 |
| Small IB4-positive dural afferent neurons | ||||||||||
| WT | 20.4 ± 0.7 | 21.7 ± 1.5 | 565 ± 71 | −54.4 ± 1.0 | 150 ± 14 | −14.9 ± 1.3 | 115.9 ± 2.9 | 4.6 ± 0.5 | −17.1 ± 1.4 | 13 |
| KO | 17.7 ± 1.0 | 21.2 ± 1.3 | 757 ± 89 | −55.3 ± 1.5 | 138 ± 11 | −15.3 ± 1.7 | 113.4 ± 4.6 | 4.9 ± 0.5 | −18.6 ± 1.6 | 20 |
***p < 0.001; two-tailed t test between the corresponding WT and KO groups.