Figure 1.

Structure of the P22-CD33 Complex

(A) Cartoon representation of the CD33 N-terminal V-set domain in rainbow coloring from blue (N terminus) to orange (C terminus). The critical sialic acid-binding residue R119 (colored orange) and compound P22 (gray) are shown as sticks.

(B) The electrostatic potential energy mapped onto the molecular surface of CD33 is shown, in the same orientation as (A), with electropositive regions colored blue and electronegative regions red. The location of R119 is indicated.

See also Figure S3 and Table S1.