The prognostic value of gastrointestinal bleeding in gastrointestinal stromal tumor: A propensity score matching analysis

Abstract

Background and objectives

Whether gastrointestinal (GI) bleeding indicates gastrointestinal stromal tumor (GIST) rupture and impacts prognosis is unclear. We examined the prognostic value of GI bleeding in GIST.

Methods

Primary GIST patients with (GB group) or without (NGB group) initial symptoms of GI bleeding were retrospectively studied. Propensity score matching (PSM) was conducted to reduce confounders.

Results

Eight hundred patients were enrolled. Male gender [odds ratio (OR) = 1.517, P = 0.011], tumors in the small intestine (OR = 2.539, P < 0.001), and tumor size 5‐10 cm (OR = 2.298, P = 0.004) increased the odds of GI bleeding; age >60 years decreased the odds (OR = 0.683, P = 0.031). After PSM, 444 patients were included (222 in each group). Relapse‐free survival (RFS) (P = 0.001) and overall survival (OS) (P = 0.002) were both superior in the GB group. In subgroup analysis, the GB group achieved a superior RFS (P = 0.005) and OS (P = 0.007) in patients with small intestine GIST, but not stomach or colorectal GIST.

Conclusions

GIST patients with age <60, male gender, tumors located in the small intestine, and tumors 5‐10 cm in size had a higher risk of GI bleeding. GIST patients with GI bleeding had a superior RFS and OS. This difference was statistically significant only in small intestine GIST.

1. INTRODUCTION

Gastrointestinal stromal tumor (GIST), with an annual incidence of 10‐15 cases per million people, is the most common mesenchymal‐derived tumor of the gastrointestinal (GI) tract.1, 2 About 69% of patients with GIST are symptomatic, and GI bleeding is the most common clinical symptom, presenting as hematemesis, hematochezia, or melena.3

GIST has a varying malignant potential ranging from small lesions with benign behavior to aggressive sarcomas.1 The modified National Institutes of Health (NIH) risk classification scheme, which encompasses 4 factors (size, mitotic count, site, and rupture), is frequently used to estimate the risk of recurrence after surgery.4 Notably, patients with tumor rupture, regardless of tumor location, tumor size, and mitotic count, are classified as high‐risk in the modified NIH criteria, because tumor rupture into the enterocoelia that occurs either spontaneously or during surgery increases the risk of tumor cell dissemination. Tumor rupture can predict survival independent of the size, mitotic count, and location of the tumor.5 However, whether GI bleeding indicates tumor rupture in the alimentary canal and can impact survival is unknown.

Our previous study demonstrated that, compared to GIST patients with GI bleeding, patients without GI bleeding showed an inferior relapse‐free survival (RFS).5 However, several recent studies have reported that GI bleeding is a negative prognostic factor.6, 7 However, these were both retrospective studies, and the reliability of these statistical results might be weakened because some characteristics that influenced prognosis were significantly different between patients who did and did not have GI bleeding.6, 7, 8 Hence, the prognostic impact of GI bleeding on GIST remains to be clarified. With the aim of achieving a more credible conclusion, the latest data from GIST patients in the Union Hospital, Tongji Medical College, Huazhong University of Science and Technology were collected, and propensity score matching (PSM), which can balance the covariates and confounders in nonrandomized studies,9 was performed. Moreover, subgroup analysis based on tumor location was conducted to further explore GI bleeding in GIST patients.

2. MATERIALS AND METHODS

2.1. Patients

Between January 2005 and December 2017, 1027 patients were diagnosed with primary GIST at the Union Hospital, Tongji Medical College, Huazhong University of Science and Technology. Among them, 800 patients were enrolled in this study. The exclusion criteria were as follows: (1) extra‐GI stromal tumors, (2) distant metastasis or invasion of the adjacent organs, (3) R1 or R2 resection, and (4) missing data and incomplete variables. Patients were divided into 2 groups: those who presented with GI bleeding (GB group) and those who presented without GI bleeding (NGB group). Demographic and clinicopathological data were collected and recurrent risk assessment was conducted according to the modified NIH criteria.4

The flow chart for extracting eligible cases and grouping is demonstrated in Figure 1. This study was approved by the Ethics Committee of Tongji Medical College, Huazhong University of Science and Technology.

Figure 1.

Patient selection flowchart

2.2. Follow‐up

Postoperative follow‐up was performed routinely (3‐6 months) by specially trained researchers. The follow‐up information, including adjuvant therapy, recurrence, and death were collected. The latest follow‐up date for the study was 1 July 2018. RFS was defined as the time from surgery to the first diagnosis of recurrent disease, and overall survival (OS) was defined as the time from surgery to death.

2.3. Propensity score matching

Propensity score matching was performed to eliminate the different distributions of covariates among individuals in the 2 groups. Seven covariates (age, gender, tumor location, tumor size, mitotic rate, tumor rupture, and adjuvant imatinib treatment) were selected to calculate the propensity score. Tumor rupture was strictly defined as tumor spillage or fracture, piecemeal resection, incisional biopsy, gastrointestinal perforation to the abdominal cavity, or blood‐tinged ascites. The PSM was conducted based on the logic of the propensity score and one‐to‐one nearest neighbor matching. The caliper was 0.02. The balance of covariates after matching was assessed using the standardized difference.10

2.4. Statistical analysis

Quantitative data were expressed as mean ± SD, and the differences were compared using an independent t test. The Chi‐square test or Fisher's exact test was used to compare differences in categorical data from different groups. Univariate and multivariate logistic regression models were constructed to explore the association of demographic and clinicopathological characteristics with GI bleeding. The survival curves were plotted by the Kaplan‐Meier method and the difference was compared by log‐rank test. SPSS software (SPSS 20.0, Chicago, IL, USA) was used for data management and statistical analyses. PSM was performed using Stata 14.0 (StataCorp, College Station, TX, USA). A 2‐tailed P < 0.05 was considered statistically significant.

3. RESULTS

3.1. Demographic data and clinicopathological characteristics

The characteristics of the entire cohort and the propensity score‐matched groups are shown in Table 1. Among the entire cohort, the median age was 56 years, and 436/800 (54.5%) of patients were men. According to the modified NIH classifications, 166/800 (20.8%) cases were classified as very low risk, 260/800 (32.5%) as low risk, 105/800 (13.1%) as intermediate risk, and 269/800 (33.6%) as high risk. Before PSM, significant imbalances in gender (P = 0.004), age (P = 0.008), tumor location (P < 0.001), tumor size (P = 0.009), recurrence risk (P = 0.011), and adjuvant imatinib therapy (P = 0.0037) were found between the 2 groups. After PSM, 222 patients comprised each of the 2 groups, and all baseline variables were more balanced (P > 0.05).

Table 1.

Comparison of demographic and clinicopathological characteristics before and after propensity score matching

Characteristics	Overall population 【N = 800 (%)】	Before matching				After matching
		GBa group【N = 236 (%)】	NGBb group【N = 564 (%)】	χ 2/t	P	GB group【N = 222 (%)】	NGB group【N = 222 (%)】	χ 2/t	P
Gender				8.188	0.004			0.037	0.847
Female	364 (45.5)	89 (37.7)	275 (48.8)			89 (40.1)	91 (41.0)
Male	436 (54.5)	147 (62.3)	289 (51.2)			133 (59.9)	131 (59.0)
Age(year)				7.064	0.008			0.100	0.752
≤60	528 (66.0)	172 (72.9)	356 (63.1)			158 (71.2)	161 (72.5)
>60	272 (34.0)	64 (27.1)	208 (36.9)			64 (28.8)	61 (27.5)
Tumor location				40.555	<0.001			1.442	0.486
Stomach	474 (59.3)	105 (44.5)	369 (65.4)			105 (47.3)	107 (48.2)
Small intestine	284 (35.5)	123 (52.1)	161 (28.6)			109 (49.1)	102 (45.9)
Colorectum	42 (5.2)	8 (3.4)	34 (6.0)			8 (3.6)	13 (5.9)
Tumor size(cm)				9.431	0.009			0.047	0.977
≤5	479 (59.9)	133 (56.4)	346 (61.3)			119 (53.6)	121 (54.5)
5‐10	223 (27.9)	82 (34.7)	141 (25.0)			82 (36.9)	81 (36.5)
>10	98 (12.2)	21 (8.9)	77 (13.7)			21 (9.5)	20 (9.0)
Mitotic index				0.062	0.969			0.767	0.681
≤5/50 HPF	638 (79.8)	187 (79.2)	451 (80.0)			173 (77.9)	180 (81.1)
6‐10/50 HPF	100 (12.5)	30 (12.7)	70 (12.4)			30 (13.5)	27 (12.2)
>10/50 HPF	62 (7.7)	19 (8.1)	43 (7.6)			19 (8.6)	15 (6.8)
Tumor rupture				0.687	0.407			2.009	0.156
No	789 (98.6)	234 (99.2)	555 (98.4)			220 (99.1)	222 (100.0)
Yes	11 (1.4)	2 (0.8)	9 (1.6)			2 (0.9)	0 (0.0)
Recurrence riskc				11.093	0.011			0.354	0.950
Very low risk	166 (20.8)	32 (13.6)	134 (23.8)			27 (12.2)	38 (12.6)
Low risk	260 (32.5)	87 (36.9)	173 (30.7)			78 (35.1)	81 (36.5)
Intermediate risk	105 (13.1)	31 (13.1)	74 (13.1)			31 (14.0)	33 (14.9)
High risk	269 (33.6)	86 (36.4)	183 (32.4)			86 (38.7)	80 (36.0)
Adjuvant imatinib				4.367	0.037			0.502	0.479
No	583 (72.9)	160 (67.8)	423 (75.0)			146 (65.8)	153 (68.9)
Yes	217 (27.1)	76 (32.2)	141 (25.0)			76 (34.2)	69 (31.1)

Abbreviation: HPF, high‐powered fields.

^aGB group: gastrointestinal bleeding group.

^bNGB group: nongastrointestinal bleeding group.

^cA risk category was assigned to all patients based on the application of the modified NIH criteria (2008 Edition).

3.2. Factors associated with GI bleeding

Univariate analysis identified a number of factors associated with increased odds of GI bleeding, including male gender [odds ratio(OR) = 1.572, P = 0.004], tumors located in the small intestine (compared to tumors located in the stomach, OR = 2.685, P < 0.001), and tumor size 5‐10 cm (compared to tumor size >10 cm, OR 2.132, P = 0.007). Patients >60 years had decreased odds of GI bleeding (OR = 0.637, P = 0.008). Multivariate analysis showed a similar result. Male patients (OR = 1.517, P = 0.011), those with tumors in the small intestine (compared to those with tumors located in the stomach, OR = 2.539, P < 0.001), and those with tumors 5‐10 cm (compared to tumors >10 cm, OR 2.298, P = 0.004) had increased odds of GI bleeding, whereas patients >60 years had decreased odds of GI bleeding (OR = 0.683, P = 0.031). The logistic analysis of factors associated with GI bleeding are reported in Table 2.

Table 2.

Logistic analysis of factors associated with GI bleeding

Characteristics	Univariate			Multivariate
	OR	95% CI	P	OR	95% CI	P
Gender
Female	ref	–	–	ref	–	–
Male	1.572	1.152‐2.144	0.004	1.517	1.099‐2.093	0.011
Age (year)
≤60	ref	–	–	ref	–	–
>60	0.637	0.456‐0.889	0.008	0.683	0.483‐0.966	0.031
Tumor location			<0.001			<0.001
Stomach	ref	–	–	ref	–	–
Small intestine	2.685	1.951‐3.696	<0.001	2.539	1.827‐3.526	<0.001
Colorectum	0.827	0.372‐1.840	0.641	0.746	0.332‐1.677	0.479
Tumor size (cm)			0.01			0.014
≤5	ref	–	–	ref	–	–
5‐10	1.513	1.079‐2.121	0.016	1.351	0.951‐1.919	0.094
>10	0.71	0.421‐1.196	0.198	0.588	0.342‐1.010	0.055
Mitotic index			0.969
>5	ref	–	–
5‐10	1.034	0.652‐1.638	0.888
>10	1.066	0.605‐1.877	0.826

Abbreviations: CI, confidence interval.; GI, gastrointestinal; OR, odds ratio.

3.3. Survival analysis

The median follow‐up time in the entire cohort was 43 (range, 3‐150) months. Before PSM, the GB group showed a better RFS (P = 0.003) and OS (P = 0.003) than the NGB group. After PSM, the 1‐, 3‐, and 5‐year RFS rates in the GB group were 97.6%, 91.2%, and 87.4%, respectively, and the corresponding rates in the NGB group were 95.1%, 85.5%, and 74.3%, respectively. The 1‐, 3‐, and 5‐year OS rates in the GB group were 99.0%, 96.8%, and 93.0%, respectively, and the corresponding rates in the NGB group were 98.6%, 91.7%, and 83.4%, respectively. RFS (P = 0.001) and OS (P = 0.002) were both superior in the GB group. Kaplan‐Meier curves are shown in Figure 2.

Figure 2.

Comparison of relapse‐free survival between the GB group and NGB group before (A) and after (C) propensity score matching. Comparison of overall survival between the GB group and NGB group before (B) and after (D) propensity score matching. GB group, gastrointestinal bleeding group; NGB group, non‐gastrointestinal bleeding group

On multivariate Cox regression analysis, GI bleeding was identified as an independent factor associated with better RFS [hazard ratio (HR) = 0.472, P = 0.001] and OS (HR = 0.441, P = 0.005; Table 3). Age (P = 0.001), tumor location (P < 0.001), tumor size (P < 0.001), and mitotic index (P < 0.001) were statistically significant independent predictors of RFS in the multivariate analysis, and age (P = 0.007), tumor size (P = 0.004), mitotic index (P < 0.001), and adjuvant imatinib therapy (P = 0.009) were independent risk factors of OS.

Table 3.

Univariate and multivariate relapse‐free and overall survival analysis

Characteristics	Relapse‐free survival						Overall survival
	Univariate			Multivariate			Univariate			Multivariate
	HR	95% CI	P	HR	95% CI	P	HR	95% CI	P	HR	95% CI	P
Gender
Female	ref	–	–				ref	–	–
Male	1.082	0.748‐1.564	0.677				1.135	0.740‐1.741	0.561
Age (year)
≤60	ref	–	–	ref	–	–	ref	–	–	ref	–	–
>60	1.75	1.210‐2.532	0.003	1.916	1.319‐2.789	0.001	1.956	1.277‐2.997	0.002	1.843	1.186‐2.865	0.007
GI‐bleeding
No	ref	–	–	ref	–	–	ref	–	–	ref	–	–
Yes	0.578	0.371‐0.900	0.015	0.472	0.299‐0.745	0.001	0.444	0.254‐0.776	0.004	0.441	0.250‐0.776	0.005
Tumor location			<0.001			<0.001			0.041			0.056
Stomach	ref	–	–	ref	–	–	ref	–	–	ref	–	–
Small intestine	2.062	1.415‐3.007	<0.001	2.075	1.397‐3.083	<0.001	1.565	0.998‐2.454	0.051	1.561	0.974‐2.501	0.064
Colorectum	2.389	1.243‐4.580	0.009	2.600	1.339‐5.047	0.005	2.196	1.062‐4.540	0.034	2.144	1.026‐4.481	0.042
Tumor size (cm)			<0.001			<0.001			<0.001			0.004
≤5	ref	–	–	ref	–	–	ref	–	–	ref	–	–
5‐10	2.914	1.928‐4.405	<0.001	2.331	1.497‐3.630	<0.001	2.366	1.449‐3.863	0.001	2.356	1.402‐3.960	0.001
>10	3.777	2.348‐6.078	<0.001	2.128	1.267‐3.574	0.004	3.486	2.003‐6.068	<0.001	2.064	1.114‐3.824	0.021
Mitotic index			<0.001			<0.001			<0.001			<0.001
≤5/50 HPF	ref	–	–	ref	–	–	ref	–	–	ref	–	–
6‐10/50 HPF	2.749	1.735‐4.354	<0.001	2.080	1.284‐3.368	0.003	2.374	1.340‐4.208	0.003	2.153	1.187‐3.904	0.012
>10/50 HPF	4.896	2.821‐8.499	<0.001	4.243	2.357‐7.640	<0.001	6.81	3.682‐12.593	<0.001	6.966	3.558‐13.641	<0.001
Tumor rupture
No	ref	–	–	ref	–	–	ref	–	–
Yes	5.277	1.929‐14.435	0.001	2.697	0.945‐7.694	0.064	1.651	0.229‐11.897	0.619
Adjuvant imatinib
No	ref	–	–	ref	–	–	ref	–	–	ref	–	–
Yes	1.575	1.069‐2.321	0.021	0.946	0.618‐1.448	0.797	0.779	0.451‐1.345	0.37	0.465	0.262‐0.826	0.009

Abbreviations: CI, confidence interval; GI, gastrointestinal; HPF, high‐powered fields; HR, hazard ratio.

3.4. Subgroup analysis based on tumor location

In the PSM groups, there were 212/444 (47.8%) patients with tumors in the stomach, 211/444 (47.5%) patients with tumors in the small intestine, and 21/444 (4.7%) patients with tumors in the colorectum. The baseline characteristics between the GB and NGB groups remained well balanced among patients with GIST derived from different regions of the GI tract (Table 4). Subgroup analysis demonstrated no significant difference in RFS and OS between the 2 groups in patients with tumors in either the stomach or the colorectum (all P > 0.05). However, in patients with GIST located in the small intestine, the GB group had a superior RFS (P = 0.005) and OS (P = 0.007) to the NGB group. Kaplan‐Meier curves are shown in Figure 3.

Table 4.

Comparison of demographic and clinicopathological characteristics before and after propensity score matching in subgroup analysis

Characteristics	Stomach				Small intestine				Colorectum
	GBa group【N = 105 (%)】	NGBb group【N = 107 (%)】	χ 2/t	P	GB group【N = 109 (%)】	NGB group【N = 102 (%)】	χ 2/t	P	GB group【N = 8 (%)】	NGB group【N = 13 (%)】	χ 2/t	P
Gender			0.207	0.649			0.0180	0.672			–	0.146c
Female	39 (37.1)	43 (40.2)			46 (42.2)	46 (45.1)			4 (50.0)	2 (15.4)
Male	66 (62.9)	64 (59.8)			63 (61.5)	56 (54.9)			4 (50.0)	11 (84.6)
Age (year)			0.676	0.411			0.188	0.665			–	1.000c
≤60	66 (62.9)	73 (68.2)			84 (77.1)	76 (74.5)			8 (100.0)	12 (92.3)
>60	39 (37.1)	34 (31.8)			25 (22.9)	26 (25.5)			0 (0.0)	1 (7.7)
Tumor size(cm)			0.093	0.955			0.050	0.975			3.231	0.199
≤5	56 (53.3)	57 (53.3)			59 (54.1)	54 (52.9)			4 (50.0)	10 (76.9)
5‐10	39 (37.2)	41 (38.3)			39 (35.8)	38 (37.3)			4 (50.0)	2 (15.4)
>10	10 (9.5)	9 (8.4)			11 (10.1)	10 (9.8)			0 (0.0)	1 (7.7)
Mitotic index			0.464	0.793			2.920	0.232			1.477	0.478
≤5/50 HPF	81 (77.1)	85 (79.4)			85 (78.0)	86 (84.3)			7 (87.5)	9 (69.2)
6∼10/50 HPF	15 (14.3)	12 (11.2)			15 13.8)	13 (12.7)			0 (0.0)	2 (15.4)
>10/50 HPF	9 (8.6)	10 (9.3)			9 (8.2)	3 (2.9)			1 (12.5)	2 (15.4)
Recurrence riskd			1.016	0.797			1.094	0.579			0.955	0.620
Very low risk	13 (12.4)	20 (18.7)			11 (10.1)	7 (6.9)			1 (12.5)	1 (7.6)
Low risk	38 (36.2)	32 (29.9)			40 (36.7)	43 (42.2)			2 (25.0)	6 (46.2)
Intermediate risk	31 (29.5)	33 (30.8)			0 (0.0)	0 (0.0)			0 (0.0)	0 (0.0)
High risk	23 (21.9)	22 (20.6)			58 (53.2)	52 (51.0)			5 (62.5)	6 (46.2)
Tumor rupture			–	0.495c			–	1.000c			–	–
No	104 (99.0)	107 (100.0)			108 (99.1)	102 (100.0)			8 (100.0)	13 (100.0)
Yes	1 (1.0)	0 (0.0)			1 (0.9)	0 (0.0)			0 (0.0)	0 (0.0)
Adjuvant imatinib			0.152	0.697			0.050	0.824			–	0.346c
No	72 (68.6)	76 (71.0)			70 (64.2)	67 (65.7)			4 (50.0)	10 (76.9)
Yes	33 (31.4)	31 (29.0)			39 (35.8)	35 (34.3)			4 (50.0)	3 (23.1)

^aGB group: gastrointestinal bleeding group;

^bNGB group: nongastrointestinal bleeding group;

^cFisher's exact test;

^dA risk category was assigned to all patients based on the application of the modified National Institutes of Health criteria (2008 Edition).

Figure 3.

Comparison of relapse‐free survival between the GB group and NGB group with GIST located in the stomach (A), small intestine (B), and colorectum (C) after propensity score matching. Comparison of overall survival between the GB group and NGB group with GIST located in the stomach (D), small intestine (E), and colorectum (F) after propensity score matching. GB group, gastrointestinal bleeding group; NGB group, nongastrointestinal bleeding group

4. DISCUSSION

Patients with GIST may present with a variety of nonspecific symptoms, including abdominal pain, bloating, GI bleeding, fatigue from anemia, and obstruction, depending on the site, size, and growth pattern of the tumor.11 About 23%‐40% of patients initially manifest with GI bleeding,12, 13, 14 which may be caused by ulceration or mucosal invasion.6, 15, 16 While “tumor rupture,” an established concept in GIST, 5, 17, 18 has been inconsistently defined as R1 resection, gross tumor spillage, and even mucosal perforation,5, 19, 20, 21, 22 whether GI bleeding is a kind of tumor rupture and increases the risk of recurrence or metastasis is unknown. There is insufficient evidence because studies focused on GIST patients with GI bleeding are rare, and the previously published studies are retrospective studies based on a limited sample size. This study is the first study using PSM to investigate GI bleeding in GIST, and had a relatively larger sample size. We demonstrated that GIST patients with GI bleeding have superior oncological outcomes to those without GI bleeding.

Among the entire cohort, the GB group and the NGB group showed significant differences in gender, age, tumor location, tumor size, and recurrence risk. Therefore, we conducted a logistic analysis to screen out the factors associated with GI bleeding. The analysis showed that tumors located in the small intestine were more prone to present with GI bleeding, which is consistent with the results reported by Liu et al6 In addition, our study found that patients with tumors 5‐10 cm in size had a higher risk of GI bleeding than patients with tumors >10 cm. This may be associated with the growth pattern of GIST, which can be defined as endoluminal, exophytic, or mixed (dumbbell‐shaped).23 Kang et al24 reported that smaller masses and lesions often protrude into the lumen, whereas larger masses and tumors often demonstrate an exophytic pattern of growth, toward the peritoneal cavity. Therefore, larger tumors may feature exophytic patterns of growth and have a lower risk of causing ulceration or mucosal invasion of the GI tract. In contrast, tumors 5‐10 cm in size might demonstrate endoluminal or mixed patterns, and therefore have a higher risk of GI bleeding.

Several retrospective studies have shown that GI bleeding was a risk factor for poor prognosis in GIST patients.6, 7, 25, 26 However, our previous study demonstrated that GI bleeding was a positive factor for RFS, and this study, which balanced the demographic data and clinicopathological characteristics between the 2 groups by PSM, showed that the GB group had superior RFS and OS. Multivariate Cox regression analysis identified age, tumor location, tumor size, mitotic index, and adjuvant imatinib treatment as independent risk factors of prognosis, which was consistent with previous studies.5, 27, 28, 29 Moreover, it also found that GI bleeding was a positive prognostic factor. Therefore, GI bleeding in GIST patients does not appear to act like tumor rupture or tumor necrosis, which is associated with poor clinical outcomes.5, 30 Additionally, as GISTs derived from different parts of the GI tract have different malignancy potentials31, 32, 33 and varying risks of GI bleeding, we conducted subgroup analysis based on tumor location. The log‐rank test revealed that the GB group had a superior outcome to the NGB group in GIST of the small intestine, whereas the difference in prognosis between the 2 groups was insignificant in GISTs of the stomach and colorectum.

The better outcomes of the GB group used to be attributed to the smaller size of the tumor.8 However, this study eliminated the difference in tumor size between the 2 groups and found that the superior outcome of the GB group was mainly because of improved outcomes in small intestine GIST. Considering that GI bleeding might make patients more vigilant than other nonspecific symptoms, such as abdominal pain or bloating, and the smaller cavity channel of the small intestine might cause an earlier presentation of bleeding than other locations, this special symptom could induce earlier medical treatment, thereby generating a superior outcome in small intestine GIST. Whether GIST with higher bleeding risk has a lower aggressive ability and whether GI bleeding can be a potential factor for risk classification of GIST needs further study.

It is infeasible to conduct a prospective randomized study to compare the clinicopathological characteristics and prognosis between GIST patients with and without GI bleeding. Therefore, PSM, which is widely used in retrospective studies,32, 33, 34 was performed here to eliminate the confounders between the 2 groups. Though some potential factors that influence the outcome of GIST patients may exist that were not included in the calculation of the propensity score, to the best of our knowledge, this study is the most sophisticated study focusing on GI bleeding in GIST patients. However, this was a study at a single center with a relatively limited number of patients, and a larger multicenter study is needed to verify its conclusions.

5. CONCLUSIONS

In summary, GIST patients with age < 60, male gender, tumors located in the small intestine, and tumors 5‐10 cm in size were more likely to manifest with GI bleeding. Compared with the NGB group, the GB group had a superior RFS and OS. This difference was statistically significant in small intestine GIST, but not in stomach or colorectal GIST.

CONFLICT OF INTEREST

The authors declare that there is no conflict of interest.

Wan W, Xiong Z, Zeng X, et al. The prognostic value of gastrointestinal bleeding in gastrointestinal stromal tumor: A propensity score matching analysis. Cancer Med. 2019;8:4149–4158. 10.1002/cam4.2328

DATA AVAILABILITY STATEMENT

All data included in this study are available upon request by contact with the corresponding author.