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. 2019 Jul 31;6(4):ENEURO.0112-19.2019. doi: 10.1523/ENEURO.0112-19.2019

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Copyright © 2019 Di et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 4. — Change in EPSC sensitivity to the calcium-permeable AMPA receptor antagonist NAS following salt loading. A, NAS reduced the mean frequency (left) and amplitude (right) of sEPSCs over time in SON neurons from salt-loaded (NaCl) rats, but not in SON neurons from control rats. B, The effect of NAS on mean sEPSC frequency (Freq), amplitude (Amp), and decay time (Decay) in SON neurons from salt-loaded rats (NaCl) and control rats, expressed as a percentage of baseline. NAS decreased the sEPSC frequency and amplitude in SON neurons from salt-loaded rats but not control rats. C, NAS caused a decrease in the mean amplitude of eEPSCs in SON neurons from salt-loaded rats, but not control rats. NAS had no effect on the paired-pulse ratio of eEPSCs (PPR) in SON neurons from either control or salt-loaded rats. D, NAS had no effect on the eEPSC rectification index in SON neurons from control rats, but reversed the increase in the rectification index in SON neurons from salt-loaded rats. Numerals in bars represent recorded cell numbers; *p < 0.05, **p < 0.01 compared to control or baseline.