TABLE 1.
Characteristics of adult KT candidates by classification of binary state frailty transitions (N = 569)a
| Factor | Stable nonfrail (n = 424) |
Nonfrail to frail (n = 51) |
Frail to nonfrail (n = 54) |
Stable frail (n = 40) |
P |
|---|---|---|---|---|---|
| Age, mean (SD) | 50.8 (14.0) | 54.9 (12.4) | 54.5 (14.5) | 54.5 (14.0) | 0.04 |
| BMI, mean (SD) | 28.2 (5.4) | 27.8 (5.7) | 29.9 (5.8) | 29.4 (7.1) | 0.08 |
| Male | 60.4 | 54.9 | 74.1 | 55.0 | 0.15 |
| Race | 0.53 | ||||
| White/Caucasian | 58.5 | 45.1 | 46.3 | 47.5 | |
| Black/African American | 35.1 | 51.0 | 48.1 | 52.5 | |
| Other | 6.4 | 3.9 | 5.6 | 0.0 | |
| Charlson Comorbidity Index, median (IQR)b | 1.0 (0.0–2.0) | 1.0 (0.0–3.0) | 2.5 (0.0–4.0) | 2.0 (1.0–4.0) | <0.001 |
| Diabetes | 25.5 | 41.2 | 42.6 | 52.5 | <0.001 |
| Cancer | 1.7 | 0.0 | 0,0 | 5.0 | 0.19 |
| Lung disease | 6.1 | 3.9 | 13.0 | 10.0 | 0.19 |
| CVD | 17.3 | 19.6 | 22.2 | 30.0 | 0.22 |
| HIV | 2.1 | 3.9 | 3.7 | 0.0 | 0.56 |
| Rheumatological disease | 7.0 | 15.2 | 5.7 | 8.6 | 0.23 |
| Cause of ESRD | 0.01 | ||||
| Glomerular | 25.0 | 31.4 | 24.1 | 22.5 | |
| Diabetes | 13.7 | 11.8 | 29.6 | 30.0 | |
| Hypertension | 30.4 | 33.3 | 37.0 | 27.5 | |
| Cystic | 11.8 | 5.9 | 3.7 | 5.0 | |
| Other | 19.1 | 17.6 | 5.6 | 15.0 | |
| Y on dialysis, median (IQR) | 2.0 (0.0–4.4) | 2.4 (0.0–5.2) | 1.3 (0.4–2.6) | 2.5 (1.0–4.2) | 0.36 |
| Type of dialysis | 0.06 | ||||
| Hemodialysis | 55.6 | 56.0 | 66.7 | 77.5 | |
| Peritoneal dialysis | 15.2 | 10.0 | 16.7 | 7.5 | |
| Not on dialysis | 29.2 | 34.0 | 16.7 | 15.0 | |
| Y between evaluation and KT, median (IQR) | 1.1 (0.5–1.9) | 1.1 (0.7–2.2) | 1.1 (0.6–1.7) | 0.9 (0.5–2.0) | 0.81 |
a
Percentages are presented unless otherwise stated. Bold indicates values that are statistically significant at a cutoff of P < 0.05.
BMI, body mass index; CVD, cardiovascular disease; ESRD, end-stage renal disease; IQR, interquartile range; KT, kidney transplantation.