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. 2019 Jul 16;11(7):342. doi: 10.3390/pharmaceutics11070342

Figure 3.

Figure 3

Intranasal immunization with T. gondii VLPs induced mucosal immunity. Mice (n = 10) were intranasally immunized with ROP4 VLPs, ROP13 VLPs, ROP4+ROP13 VLPs and ROP(4 + 13) VLPs. Mice samples were collected at day 30 after challenge infection with T. gondii ME49. To confirm the activation of mucosal immunity, we identified IgG and IgA antibody responses from vaginal secretions, urine, feces and intestines. IgG and IgA antibody responses from vaginal secretions ((A,B), * p < 0.05, *** p < 0.001). IgG and IgA antibody responses in urine ((C,D), * p < 0.05, *** p < 0.001). IgG and IgA antibody responses in feces ((E,F), * p < 0.05, *** p < 0.001). IgG and IgA antibody response in intestine ((G,H), * p < 0.05, *** p < 0.001).