Table 2.

Microbial production of resveratrol and their derivatives.

Microbial Host	Incorporated Genes	Host Engineered	Substrate	Titer (mg/L)	References
Escherichia coli (Resveratrol)
E. coli BW27784	4CL(A. thaliana) STS (A. hypogaea)		p-Coumaric acid	0.16	[103]
E. coli BL21(DE3)	4CL (N. tabacum) STS (V. vinifera)		p-Coumaric acid	16	[68]
E. coli BL21(DE3)	Pal (R. rubra) 4CL (L. erythrorhizon) STS (A. hypogaea)		Tyrosine	37	[101]
E. coli BRB	4CL (L. erythrorhizon) STS (A. hypogaea) ACC (C. glutamicum) F3H and FLS (Citrus)		Cinnamic acid	155	[104]
			p-Coumaric acid	171
E. coli BW27784	4CL (A. thaliana) STS (A. hypogaea)		p-Coumaric acid	105	[99]
E. coli BW27784	4CL (A. thaliana) STS (A. hypogaea)		p-Coumaric acid	404	[71]
	4CL (A. thaliana) STS (V. vinífera)			1380
	4CL (P. crispum) STS (A. hypogaea)			142
	4CL (P. crispum) STS (V. vinífera)			610
	4CL (A. thaliana) STS (V. vinífera)		p-Coumaric acid and cerulenin	2340	[71]
E. coli C41 (DE3)	TAL (S. espanaensis) 4CL (S. coelicolor) STS (A. hypogaea)		p-Coumaric acid	104	[72]
E. coli BW25113 (DE3)	TAL (R. glutinis) 4CL (P. crispum) STS (V. vinifera)	Inactivation of tyrR and deletion of trpED by chromosomal integration	Glucose	4.6	[77]
E. coli BW27784 (DE3)	4CL (A. thaliana) STS (V. vinífera)		p-Coumaric acid	1600	[105]
E. coli BL21 (DE3)	TAL (R. glutinis) 4CL (P. crispum) STS (V. vinifera) matB and matC (R. trifolii)		L-Tyrosine	35.02	[73]
E. coli BL21 (DE3)	4CL::STS, 4CL (A. thaliana)- STS (A. hypogaea) fusion enzyme		p-Coumaric acid	80.5	[100]
E. coli BL21 (DE3)	TAL (T. cutaneum) 4CL (P. crispum) STS (V. vinifera) matB and matC (R. trifolii) tyrAfbr and aroGfbr (E. coli K12)	Down-regulation of fabD, fabH, fabB, fabF, fabI	Glucose	304.5	[106]
E. coli BW25113	4CL2 (P.crispum) STS (V. vinifera)		p-Coumaric acid	268.2	[14]
E. coli C41 (DE3)	TAL (S. espanaensis) 4CL (S. coelicolor) STS (A. hypogaea)		Glucose	5.2	[95]
E. coli BL21(DE3)	TAL (S. espanaensis) 4CL (A. thaliana) STS (A. hypogaea)		Tyrosine	114.2	[102]
E. coli W(pheA-) Rg E.coli W-Vv	TAL (R. glutinis) tktAfbr and aroG fbr (E. coli) 4CL (S. coelicolor) STS (V. vinífera)	Deletion of pheA	Glycerol	22.58	[49]
Non- E. coli (Resveratrol)
C. glutamicum DelAro3	STS (A. hypogaea) 4CL (P. crispum)	Deletion of phdB, pcaF and pobA	p-Coumaric acid	12	[89]
			p-coumaric acid + cerulenin	158
C. glutamicum DelAro3	TAL (F. johnsoniae) 4CL (P. crispum) STS (A. hypogaea) aroH (E. coli)	Deletion of phdB, pcaF, qsuB and pobA	Glucose	12	[90]
			Glucose+ cerulenin	59
			Glucose(40 g/L)	4
			Glucose(80 g/L)	12
			Glucose (Fed-batch)	7
S. cerevisiae W303-1A	4CL (A. thaliana) STS (A. hypogaea)		p-Coumaric acid	3.1	[70]
S. cerevisiae WAT11	4CL (A. thaliana):STS (V. vinifera)		p-Coumaric acid	5.25	[107]
S. cerevisiae WAT11	TAL (R. sphaeroides) 4CL::STS, 4CL (A. thaliana)-STS V. vinifera) fusionenzyme		Tyrosine	1.9	[108]
S. cerevisiae CEN. PK102-5B	TAL (H. aurantiacus) 4CL (A. thaliana) VST (V. vinifera)	Overexpression of aro4, aro7, and acc1	Glucose (fed-batch)	415.65	[82]
			Ethanol (fed-batch)	531.41
S. cerevisiae ST4990	PAL (A. thaliana) C4H (A. thaliana) 4CL (A. thaliana) VST (V. vinifera) ACS (S. enterica) Overexpression of atr2 (A. thaliana)	Overexpression of aro4, aro7, and acc1 and deletion of aro10	Glucose (Fed-batch)	812	[69]
S. cerevisiae DHS2001	STS (A. hypogaea) 4CL (S. coelicolor)	Deletion of pks	p-Coumaric acid	0.4	[92]
L.lactis	TAL, 4CL, STS, ACC (different sources)		L-Tyrosine	0.45-1.37	[109]
Industrial Brazilian S. cerevisiae strain	STS (V. vinifera) 4CL (A. thaliana)		p-Coumaric acid	391	[83]
Escherichia coli (Resveratrol derivatives)		Substrate	Derivatives
E. coli C41 (DE3)	TAL (S. espanaensis) 4CL (S. coelicolor) STS (A. hypogea) Glycosyltransferase YjiC (Bacillus spp.)	Glucose	3-O-resveratrol β-D-glucoside	2.5	[110]
			4′-O-resveratrol β-D-glucoside	7.5
E. coli BL21-CodonPlus (DE3)-RIPL	VvROMT (V. riparia)	Resveratrol	Pinostilbene	0.16	[111]
			Pterostilbene	0.04
	SbROMT (S. bicolor)		Pinostilbene	34
			Pterostilbene	0.16
E. coli C41(DE3)	TAL (S. espanaensis) 4CL (S. coelicolor) STS (A. hypogea) SbOMT3, SbOMT1	Glucose	3,5-Dihydroxy-4′-methoxystilbene	2.50.2	[95]
			5-Hydroxy-3,4′-dimethoxystilbene
E. coli W3110	4CL(S.coelicolor A3), STS (V.vinifera)	Cinnamic acid	Pinosylvin	34.89	[112]
	4CL(S. coelicolor A3), STS (V. vinifera) + reduced expression level of fabI gene	Cinnamic acid	Pinosylvin	52.67
E. coli BW27784	4CL1(A. thaliana) STS(A. hypogea)	Caffieic acid	Piceatannol	13	[99]
E. coli BLR(DE3)	PAL(Rhodotorula rubra) 4CL(Lithospermum erythrorhizon) STS(A. hypogea) ACC(Corynebacterium glutamicum)	Phenylalanine	Pinosylvin	20	[104]
		Tyrosine	Pinostilbene	18
			Pterositibene	5.8
	PAL(Rhodotorula rubra) 4CL(Lithospermum erythrorhizon) STS(A. hypogea) ACC(Corynebacterium glutamicum) +OsPMT (Oryza sativa)	Phenylalanine	Pinosylvin monomethyether	27
			+Pinosylvin dimethyl ether	27
E. coli BL21(DE3)	PAL (P. crispum) 4CL(S.coelicolor) STS [Pinus strobus (two mutated T248A; Q361R)] Cerulenin	Glucose/phenylalanine	Pinosylvin	91	[91]
Non-E. coli hosts (Resveratrol derivatives)
C. glutamicum DelAro4	4CL (P. crispum), STS (A. hypogea) OMT (V. vinifera):MalE (E. coli) metK (E. coli)	p-Coumaric acid	Pterostilbene	42	[113]
S. cerevisiae WAT11	4CL (A. thaliana), STS (V. vinifera) ROMT (V. vinifera)	Resveratrol	Pterostilbene	150	[114]
		p-Coumaric acid	Pterostilbene	2
S. cerevisiae ST4993	thaliana (PAL, C4H, 4CL2) STS (V. vinifera) + feedback insensitive alleles of DHAP synthase (ScARO4K229L) and chorismate mutase (ScArO7G141S) + shikimate kinase aroL + deregulated variant of ACC1 + non-regulated version of acetyl-CoA synthase (ACS) + deletion of phenylpyruvate decarboxylase ARO10 + cytochrome P450 reductases ATR2 and CYB5 + SbROMT (Sorghum bicolor)	Glucose	Pterostilbene	5.5	[69]
S. cerevisiae ST4994	All the components of Strain ST4993 along with VvROMT(V.vinifera) instead of SbROMT		Pterostilbene	3.5