Table 1.
In silico normalized free energy of binding (ΔGbind/N) and its major components (binding enthalpy ΔHbind/N and entropy variation –TΔSbind/N) for G4–G6 TEA-core and NH3-core PAMAMs in complex with heat shock protein 27 (Hsp27) small interfering RNA (siRNA) at pH 7.4 and 0.15 M NaCl. The normalization factor N is the generation-specific total number of charged dendrimer terminal groups (N). All values are expressed in kcal/mol1. Adapted from [35] with permission of John Wiley and Sons.
| TEA-Core PAMAMs | NH3-Core PAMAMs | |||||
|---|---|---|---|---|---|---|
| G | ΔGbind/N | ΔHbind/N | −TΔSbind/N | ΔGbind/N | ΔHbind/N | −TΔSbind/N |
| 4 | −7.57 1 | −9.82 | 2.25 | −4.57 | −8.02 | 3.45 |
| 5 | −14.9 | −17.9 | 3.02 | −11.5 | −16.0 | 4.43 |
| 6 | −17.0 | −20.5 | 3.55 | −14.1 | −18.8 | 4.77 |
1 Standard deviation for all data in Table 1 is less that 1%.