Table 2.
Summary of nanoformulation curcumin and chemotherapeutic drugs in vitro.
| Types of Cancer | Co-Delivery System | Treatment | Cancer Cell Lines | Findings | References |
|---|---|---|---|---|---|
| Colon cancer | Cationic polymeric nanoparticles | Camptothecin and curcumin | Colon-26 cells | Enhances synergistic effects of anticancer activity | [125] |
| Liver cancer | Lipid nanoparticle | Curcumin and doxorubicin | HepG2 cells | Enhance cytotoxicity and decrease inhibitory concentration in HepG2 cells | [129] |
| Breast cancer | Liposomal | Paclitaxel and curcumin | MCF-7 cell lines | Effectively kills the cancer cells compared to individual treatment | [130] |
| Breast cancer | Dendritic chitosan grafted methoxy polyethylene glycol (mPEG) coated magnetic nanoparticles | Doxorubicin and methotrexate | MCF7 cell lines | Enhances synergistic effects and alleviates adverse outcome | [128] |
| Breast cancer | Transferrin-decorated nanoparticles | Curcumin and doxorubicin | MCF-7 cells | Combination of transferrin-poly(ethylene glycol)-curcumin (Tf-PEG-CUR) and doxorubicin nanoparticle exhibited higher cytotoxicity in MCF-7 cells compared with Tf-PEG-CUR nanoparticle alone | [131] |
| Colon cancer | PEGylated long-circulating liposomes |
Curcumin and doxorubicin | C26 murine colon cancer cells | Exerts strong antiproliferative effects via inhibition of the angiogenic/inflammatory proteins such as TNF-α, TIMP-2, and IL-6 | [132] |
| Breast cancer | Albumin nanoparticles | Curcumin and doxorubicin | MCF-7 resistant breast cancer cells | Shows lower viability than the cells treated with a combination of curcumin and albumin nanoparticle or combination of doxorubicin and albumin nanoparticle | [133] |
| Liver cancer | Biotin-/lactobionic acid–modified poly(ethylene glycol)-poly(lactic-co-glycolic acid)-poly(ethylene glycol) (BLPP) copolymer | Curcumin and 5-FU | HepG2 cells | Exhibits higher cellular uptake, strong cytotoxicity for tumor cells | [134] |
| Pancreatic cancer | Iron oxide nanoparticles | Curcumin and gemcitabine | Human pancreatic cancer (HPAF-II and Panc-1) cell lines | Effectively delivers bioactive curcumin to pancreatic cells, simultaneously enhances gemcitabine uptake | [135] |
BLPP: biotin-/lactobionic acid–modified poly(ethylene glycol)-poly(lactic-co-glycolic acid)-poly(ethylene glycol); IL–6: interleukin-6; TIMP-2: tissue inhibitor of metalloproteinases 2; TNF-α: tumor necrosis factor α; 5-FU: 5-fluorouracil.