The effects of sesame lignans on a forced swim test in young and old mice. Values are the mean ± SEM. Statistical analyses were performed using a one-way ANOVA followed by a Tukey–Kramer post hoc analysis. Different letters indicate significant differences (p < 0.05). Experimental groups are indicated as: Young control, fed basal diet (YC, n = 8), young, fed basal diet supplemented with 0.05% sesame lignans (YS0.05, n = 7), old control, fed basal diet (OC, n = 9), old, fed basal diet supplemented with 0.02% sesame lignans (OS0.02, n = 12), and old, fed diet supplemented with 0.05% sesame lignans (OS0.05, n = 11).