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Proximal tubule-specific deletion of NHE3 in the kidney doesn’t alter the hypertensive response to L-NAME treatment in male and female PT-Nhe3−/− mice (A), compared with male and female WT mice. However, L-NAME had an antinatriuretic effect in both WT and PT-Nhe3−/− mice (D). **P<0.01 vs. basal of the same strain of mice; ++P<0.01 vs. male WT or PT-Nhe3−/− mice. N=9–10 per group.
