TABLE I.

Top EPIC CpGs with differential methylation in upper lobe macrophages associated with genes of known function

Name	Chromosome	Coordinate	Strand	UCSC Ref Gene Group	Gene	Δβ value	p Value	FDR p Value
cg22265796	chr19	16254043	+	5′-UTR	HSH2D	0.1070	4.05 × 10−6	0.013
cgl9307883	chr19	10484624	+	Body	TYK2	0.1038	8.89 × 10−6	0.017
cg07676849	chr11	71845665	−	TSS1500	FOLR3	0.0747	1.02 × 10−5	0.018
cgl7323256	chr12	52445897	−	5′-UTR/Body	NR4A1	0.0507	1.33 × 10−5	0.019
cg00889217	chr12	9233083	−	Body	A2M	−0.082	1.98 × 10−5	0.026
cgl3427753	chr6	45406009	−	Body	RUNX2	0.049	4.76 × 10−5	0.032
cg25648980	chr12	51719079	+	TSS1500	BIN2	0.0484	4.77 × 10−5	0.032
cg02290197	chr7	26370519	+	5′-UTR	SNX10	0.0508	3.90 × 10−5	0.032
cgl1259727	chr2	175465297	−	5′-UTR	W1PF1	0.0516	4.33 × 10−5	0.032
cgl8255141	Chr12	6487113	−	TSS1500	SCNN1A	0.0742	4.79 × 10−5	0.032
cgl6711835	chr5	59558467	−	5′-UTR	PDE4D	0.0747	3.80 × 10−5	0.032
cg14975420	Chr10	91096289	+	5′-UTR/Body	IFIT3	0.0479	5.95 × 10−5	0.033
cg06086177	chr16	73090646	+	5′-UTR	ZFHX3	0.0465	7.92 × 10−5	0.038
cgl3126638	Chr12	6487080	+	TSS1500	SCNN1A	0.0545	1.01 × 10−4	0.040
cg26118047	chr2	29320360	+	TSS200	CLIP4	0.0590	1.40 × 10−5	0.046

Δβ, increase in the proportion of methylated alleles in upper lobe cells; TSS, transcription start site; UCSC, University of California, Santa Cruz.