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Intracellular compartmentalization of dTTP synthesis in T. brucei. Black arrows indicate the reaction catalyzed by each enzyme. Dashed black arrows refer to a series of reactions catalyzed by several enzymes that may occur in the cytosol. CDA, cytidine deaminase (Tb927.9.3000); DHFR-TS, dihydrofolate reductase-thymidylate synthase (Tb927.7.5480); TK, thymidine kinase (Tb927.10.880); dUTPase, deoxyuridine 5′-triphosphate nucleotidohydrolase (Tb927.7.5160).
