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. 2019 Jun 5;140(6):500–513. doi: 10.1161/CIRCULATIONAHA.119.041059

Figure 5.

Figure 5.

Hhipl1 deficiency reduces atherosclerosis in Hhipl1−/−;Apoe−/− and Hhipl1−/−;Ldlr−/− mice. A, Representative Oil Red O–stained (ORO) aortas from Hhipl1+/+;Ldlr−/− and Hhipl1−/−;Ldlr−/− mice. B, Quantification of atherosclerosis in aortas of mice of each genotype as a percentage of total aorta area (n=18 vs n=19). C, Representative microphotographs of ORO-stained aortic root sections from Hhipl1+/+;Ldlr−/− and Hhipl1−/−;Ldlr−/− mice. D, Aortic root lesion area (9 sections per mouse, n=6 per group). E, ORO-stained aortas from Hhipl1+/+;Apoe−/− and Hhipl1−/−;Apoe−/− mice. F, Quantification of atherosclerosis in the aortas of mice of each genotype (n=19 vs n=18). G, ORO-stained aortic roots from Hhipl1+/+;Apoe−/− and Hhipl1−/−;Apoe−/− mice. H, Aortic root lesion area (9 sections per mouse, n=10 vs n=6). Bars, 2 mm (A and E); bars, 200 μm (C and G). Error bars represent mean±CI. HHIPL1 indicates hedgehog interacting protein-like 1. *P≤0.05, ***P≤0.001.