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. 2019 Jun 25;140(4):270–279. doi: 10.1161/CIRCULATIONAHA.118.038814

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© 2019 The Authors.

Circulation is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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Figure 1. — MR estimates for the effect of genetically lower systolic blood pressure through the ACE inhibitor, β-blocker, and calcium channel blocker variants, respectively, on risk of coronary heart disease and stroke, compared with randomized, controlled trial meta-analysis results.³ ACE indicates angiotensin-converting enzyme; IVW, inverse variance weighted; and MR, Mendelian randomization.