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. Author manuscript; available in PMC: 2019 Aug 13.
Published in final edited form as: Leukemia. 2019 Feb 13;33(8):1934–1943. doi: 10.1038/s41375-019-0402-3

Figure 4: Mutant allele frequencies suggest diverse modes of clonal evolution upon chemotherapy exposure.

Figure 4:

Variant allele frequencies (VAF) in four specimens with WT1 mutant clones are represented as the height of color-coded clones, with full height of allele frequency axis corresponding to a mutant allele frequency of 1. Simplest models of clonal architecture are shown, with additional models possible. Each hypothesized subclone is represented by a different color. (a) Specimen PASFHK in Group 2, largest VAF at diagnosis was 0.96 for WT1 R430P; largest VAF at induction failure was 0.38 for WT1 R430P. (b) Specimen PATJMY in Group 1, largest VAF at diagnosis was 0.53 for WT1 S381, largest VAF at induction failure was 0.47 for CHMP6 E108stop. (c) Specimen PASTZK in Group 2, largest VAF at diagnosis was 0.77 for PHF6 R370stop, largest VAF at induction failure was 0.37 for TP53 R273C. (d) Specimen PARXYR in Group 1, largest VAF at diagnosis was 0.57 for RBAK V708I, largest VAF at induction failure was 0.43 for GPR137B T182M.