Table 2.

Association Between Gene Modules and Measures of Lung Function After Adjustment for Confounders

Transcriptomic Module	Trait	β (95% CI)	P Value
Dark green, adaptive immunity	Post-BD FEV1/FVC ratio	−0.0009 (−0.0018 to 4.7 × 10−5)	.064
Dark gray, cell cycle	Baseline FEV1, L	−0.0233 (−0.1696 to 0.123)	.755
	Baseline FEV1/FVC ratio	0.0013 (0.0005 to 0.0021)	.002a
	Post-BD FEV1/FVC ratio	0.0014 (0.0005 to 0.0023)	.004a
Dark olive green, asthma microRNAs	Post-BD FEV1/FVC ratio	−0.0005 (−0.0014 to 0.0004)	.29
	FEV1 BD response	0.0008 (0.0001 to 0.0015)	.023a
Pink, translational	Baseline FEV1/FVC ratio	0.0009 (0.0001 to 0.0017)	.031a
Plum, innate immunity	PD20	0.0078 (0.0041 to 0.0116)	< .001
	Baseline FEV1/FVC ratio	−0.0008 (−0.0016 to 1.5 × 10−5)	.055
	Post-BD FEV1/FVC ratio	−0.001 (−0.0019 to −0.0001)	.027a
Yellow, transcriptional	FEV1 BD response	−0.0007 (−0.0014 to 3.0 × 10−5)	.062

Adjusted for age, height, weight, sex, and treatment regimen. BD = bronchodilator. See Table 1 legend for expansion of other abbreviation.

^aSignificant at 95% confidence.