Figure 7.
Regional selectivity of diazinon, displayed as the main treatment effect collapsed across dose, sex and age: (A) HC3 binding, (B) ChAT activity, (C) HC3/ChAT ratio, (D) nAChR binding, (E) 5HT1A receptors, (F) 5HT2 receptors. Regional selectivity was statistically significant across the presynaptic ACh markers (HC3, ChAT), as evidenced by a treatment × region interaction (p < 0.02); values were significantly different from control for frontal/parietal cortex (f/p, p < 0.03), temporal/occipital cortex (t/o, p < 0.0004) and hippocampus (hp, p < 0.003) but not for striatum (st), midbrain (mb) and brainstem (bs). Likewise, for the adaptive receptor markers (nAChR binding, 5HT1A receptors, 5HT2 receptors), regional selectivity was apparent (treatment × region interaction, p < 0.02), with significant differences for frontal/parietal cortex (p < 0.0001), temporal/occipital cortex (p < 0.004) and midbrain (p < 0.05), but not brainstem.