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. 2019 Jul 9;9(17):4993–5008. doi: 10.7150/thno.35665

Figure 6.

Figure 6

The upstream and downstream blocking treatment relieves YAP nuclei translocation and Smad signaling activation in the lung. (A-D) Western blot analysis of nuclear extracts (A, C) and cytoplasmic extracts (B, D) from whole lung lysates at day 56 following different treatments of mice. Analysis of YAP expression. (E) Quantification of YAP level is shown. (F-G) Western blot analysis of total extracts from whole lung lysates at day 56 following different treatments of mice. Analysis of p-Smad2 and Smad2/3 expression. (H) Quantification of the p-Smad2 level is shown. (I-J) Western blot analysis of total extracts from whole lung lysates at day 56 following different treatments of mice. Analysis of Smad7 expression. (K) Quantification of Smad7 level is shown. (E, H, K) Data shown are representative of three independent experiments. Error bars indicate mean ± SD (*, P < 0.05; **, P < 0.01; ***, P < 0.001).