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. 2019 Jul 9;9(18):5282–5297. doi: 10.7150/thno.32268

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This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.

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Bio-distribution of M-PHMs/miR-124 in vivo. (A) Real-time fluorescence imaging of AIA rat injected with the naked Cy5-miR-124, PHMs/Cy5-miR-124 or M-PHMs/Cy5-miR-124 (Cy5-miR-124=2 nmol) via the tail vein was obtained at 2 and 4 h after administration. (B) Ex vivo imaging of the paws and organs excised from AIA and normal rats was imaged at 6 h after injection. The AIA rat injected with saline and the normal rat injected with M-PHMs/Cy5-miR-124 were set as the blank and negative control, respectively. Images were obtained by IVIS^R In Vivo Imaging System with an optimized parameter (excitation, 640 nm; emission, 700 nm).