CXCL cytokines are associated with poor prognosis in RCC and in HSNCC. 446 RCC and 494 HNSCC patients were analyzed using the “The Cancer Genome Atlas (TCGA)”. The levels of CXCL1/2/3/5/6/7/8 mRNA correlated with disease/progression free survival (DSF/PFS) or with overall survival (OS). The third quartile value of CXCL expression was chosen as the reference. Statistical significance (p values) is indicated.