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. 2019 May 24;68(8):1591–1603. doi: 10.2337/db18-1088

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© 2019 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at http://www.diabetesjournals.org/content/license.

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Localization of 5-HT_2CR and BBS1 in the secretory pathway. A: GFP-tagged 5-HT_2CR localizes in the endosome (Cav-1) but not in the lysosome (LAMP1), Golgi (RSAC1), or early endosome (EEA1) in IMCD3-Bbs1^−/− cells. B: Colocalization of 5-HT_2CR–GFP and Cav-1 is only partial when the expression of 5-HT_2CR–GFP is high. C: RFP-tagged BBS1 colocalizes with GFP-tagged Rab5-GTP, Rab7-GTP, and CD63 (markers of the late endosome) but not with markers of Golgi or early endosome (EEA1) in HEK 293 cells. Scale bars, 10 μm.