Figure 1.

Profiled 5hmC loci show a distinct genomic pattern. In contrast to 5mC, 5hmC loci are, in general, biased toward the lower end of modification levels and show a distinct genomic distribution pattern of being enriched in gene bodies. (A) Comparison of the cumulative proportions between 5hmC and 5mC in terms of modification level (β-value); (B) 5hmC modifications are, in general, negatively correlated with 5mC; In (A,B), the dotted lines indicate boundaries of the cumulative proportion. Comparison of the genomic distributions between (C) 5mC and (D) 5hmC in PDAC tumors and adjacent tissues.