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Effect of powdered aliskiren (ALIS) and nanoparticle-loaded aliskiren (NP ALIS) on vasoactivity of mesenteric artery. Endothelium-dependent relaxations (A), contractions induced by exogenous noradrenaline (B), neurogenic contractions (C), and contractions induced by high concentration of KCl (D). Values represent mean ± SEM of 6 measurements. Significant differences: * (**) (***) p < 0.05 (0.01) (0.001) ALIS or NP ALIS vs. CTRL.
