Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Regulatory variants as modifiers. Coding region variants on lower-expressed haplotypes are expected to lead to decreased penetrance whereas coding region variants on higher-expressed haplotypes are expected to increase penetrance (reprinted with permission from Springer Nature: Nature Genetics, reference29).
