Table 1.
Percent survival (% S) at 24 hr of rats treated with nitrophenyl isopropyl methylphosphonate (NIMP; sarin surrogate; 0.6 mg/kg SC) or nitrophenyl ethyl methylphosphonate (NEMP; VX surrogate; 0.65 mg/kg SC) followed by atropine (0.65 mg/kg IM) ± oxime (2-PAM or novel oximes; 0.146 mmol/kg IM) at 25 (NIMP) or 30 min (NEMP). S/T=number surviving to 24 hr/number treated. Odds ratios are for survival from novel oximes alone or in combination with 2-PAM to survival from 2-PAM alone; number greater than 1 indicates improved survival of novel oxime compared to 2-PAM; probability of statistical significance was set at 0.1.
| NIMP | NEMP | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Odds | P | Odds | P | |||||||
| Oxime | Time, h | S/T | % S | Ratio | Value | Time, h | S/T | % S | Ratio | Value |
| None | 1.5 | 0/20 | 0 | 2 | 0/20 | 0 | ||||
| 2-PAM | 2 | 8/20 | 40 | 2.5 | 6/20 | 33 | ||||
| Oxime 1 | 1.5 | 13/20 | 65 | 2.785 | 0.117 | 2 | 15/20 | 75 | 6.993 | 0.006 |
| Oxime 20 | 1.5 | 11/20 | 55 | 1.834 | 0.344 | 4 | 13/20 | 65 | 4.926 | 0.030 |
| Ox1+2-PAM | 2.5 | 11/15 | 73 | 4.132 | 0.056 | 4 | 8/15 | 53 | 2.667 | 0.168 |
| Ox20+2-PAM | 3 | 13/15 | 80 | 9.708 | 0.010 | 4 | 8/15 | 53 | 2.667 | 0.168 |