Correction to: Journal of Neuro-Oncology (2019) 142:211–221 10.1007/s11060-019-03104-3
Issues with data analysis have recently been highlighted by a reader of our article. These have been addressed with changes to Tables 2 and 4, as shown below, and Online Resources 5–7. T2 and peritumoral signal are no longer prognostic factors on simple pooled (Online Resource 5) and IPD (Table 4) analyses respectively. In Table 5, the number of patients which informed the outcomes symptom development and intervention were 575 and 947 respectively; 69 developed symptoms (pooled proportion %8.4 [95% CI 2.8–16.7], I2 = 88.9%). These included motor and cognitive deficits (n = 1). We apologise to the readership of the Journal of Neuro-Oncology for these errors and thank the reader for helping us identify them.
Table 2.
Baseline clinical and radiological characteristics
| No. of studies informing characteristic | No. of valid cases informing characteristic (%) | Characteristics | Total | Surgery | SRS | Active monitoring | P | |
|---|---|---|---|---|---|---|---|---|
| 18 | 2050 | N. of patients (%) | 2050 | 560 (27.3) | 450 (22.0) | 1040 (50.7) | ||
| 13 | 803 (39.2) | Mean age, years (SD) | 63.1 (6.9) | 61.5 (4.7) | 54.9 (NR)b | 64 (6.9) | < 0.001 | |
| 17 | 1948 (95.0) | Sex, N (%) | Female | 1549 | 369 (23.8) | 363 (23.4) | 817 (52.7) | 0.539 |
| Male | 399 | 89 (22.3) | 87 (21.8) | 223 (55.9) | ||||
| 16 | 1495 (72.9) | Location, N (%)a | Non-skull base | 1024 | 277 (27.1) | 235 (22.9) | 512 (50.0) | < 0.001 |
| Convexity | 431 | 126 | 86 | 219 | ||||
| Parafalcine | 245 | 61 | 71 | 113 | ||||
| Parasagittal | 151 | 42 | 36 | 73 | ||||
| Tentorial | 62 | 12 | 28 | 22 | ||||
| Intraventricular | 26 | 4 | 12 | 10 | ||||
| Skull base | 471 | 106 (22.5) | 154 (32.7) | 211 (44.8) | ||||
| Anterior midline | 112 | 22 | 43 | 47 | ||||
| Sphenoid wing | 98 | 25 | 11 | 62 | ||||
| Posterior fossa - lateral and posterior | 52 | 23 | 12 | 17 | ||||
| Posterior fossa - midline | 138 | 17 | 87 | 34 | ||||
| 15 | 888 (43.3) | Mean diameter, cm (SD) | 2.14 (0.61) | 2.11 (0.42) | 1.73 (NR)b | 2.19 (0.66) | <0.001 | |
| 10 | 615 (30.0) | Calcification, N (%) | No | 394 | 64 (16.2) | NR | 330 (83.8) | 0.177 |
| Yes | 221 | 27 (12.2) | NR | 194 (87.8) | ||||
| 5 | 298 (14.5) | Tumor signal intensity, N (%) | Hyperintense | 120 | 40 (33.3) | NR | 80 (66.6) | 0.237 |
| Iso/hypointense | 178 | 48 (27.0) | NR | 130 (73.0) | ||||
| 12 | 1107 (54.0) | Peritumoral edema, N (%) | Yes | 144 | 47 (32.6) | 24 (16.7) | 73 (50.7) | |
| No | 963 | 145 (15.1) | 365 (37.9) | 453 (47.0) |
NR not reported, SRS stereotactic radiosurgery
aOne study which dichotomized location into supratentorial and infratentorial was excluded [15]
bAvailable in one study which did not report SD [25]
Table 4.
Growth dynamics and symptom development during active monitoring stratified by baseline characteristics
| Factor | Mean/median AGR (cm3/year) | P | Mean/median RGR (%/year) | P | Symptom development, yes/total (%) | OR (95% CI) | MLR Pa | |
|---|---|---|---|---|---|---|---|---|
| Location | Non-skull base | 7.97/0.68 | 0.747 | 70.2/17.0 | 0.405 | 12/60 (20.0) | 0.116 | |
| Skull base | 5.82/2.93 | 28.1/17.2 | 5/25 (20.0) | |||||
| Diameter | ≥ 3.0 cm | 19.7/5.91 | 0.004 | 114/24.7 | 0.091 | 15/27 (55.5) | 12.16 (5.56–18.78) | < 0.001 |
| < 3.0 cm | 1.56/0.46 | 31.4/12.7 | 2/58 (3.45) | |||||
| Calcification | No | 19.0/19.0 | NA | 141/141 | NA | 1/1 (100) | ||
| Yes | NR | NR | NR | |||||
| Tumor signal intensity | Hyperintense | NR | NA | NR | NA | NR | ||
| Iso/hypointense | NR | NR | NR | |||||
| Peritumoral edema | Yes | NR | NA | NR | NA | NR | ||
| No | 2.32/0.62 | 19.7/13.2 | 1/29 (3.45) |
AGR absolute growth rate, RGR relative growth rate, MLR multi-level regression, NA not applicable, NR not reported
aPerformed to 50 iterations
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Abdurrahman I. Islim, Midhun Mohan and Richard D. C. Moon contributed equally to the manuscript.
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