Table 1.
Characteristics of Ghsr+/+ and Ghsr−/− male and female mice
| Variable | Male |
Female |
||
|---|---|---|---|---|
|
Ghsr+/+ |
Ghsr−/− | Ghsr+/+ | Ghsr−/− | |
| Body composition | (n = 12) | (n = 9) | (n = 12) | (n = 8) |
| % lean mass | 75.8 ± 1.9 | 76.5 ± 2.0 | 72.5 ± 1.6 | 73.5 ± 1.4 |
| % fat mass | 11.8 ± 1.6 | 10.6 ± 2.1 | 13.9 ± 1.9 | 13.2 ± 1.7 |
| % fluid | 4.7 ± 0.3 | 4.8 ± 0.2 | 5.2 ± 0.3 | 5.2 ± 0.4 |
| Body weight before 6-h fast (g) | 25.2 ± 2.0 (n = 21) | 23.3 ± 1.9 (n = 23)* | 20.3 ± 1.4 (n = 23) | 20.4 ± 1.0 (n = 17) |
| Body weight before 16-h fast (g) | 24.9 ± 2.1 (n = 21) | 22.9 ± 2 (n = 23)* | 20.1 ± 1.4 (n = 22) | 19.7 ± 1.1 (n = 17) |
| Body weight after 16-h fast, before IPGTT (g) | 20.2 ± 1.5 (n = 12) | 19.7 ± 1.9 (n = 9) | 17.1 ± 1.1 (n = 12) | 17.0 ± 1.4 (n = 7) |
| Weight loss over 16-h fast (g) | 3.4 ± 0.4 (n = 12) | 3.0 ± 0.5 (n = 9)* | 2.3 ± 0.3 (n = 12) | 2.5 ± 0.3 (n = 7) |
| Fasting glucose, 6-h IPGTT (mg/dL) | 154.3 ± 21.1 (n = 21) | 141.9 ± 18.6 (n = 23)* | 135.9 ± 16.6 (n = 23) | 133.8 ± 15.1 (n = 17) |
| Fasting glucose, 16-h IPGTT (mg/dL) | 77.3 ± 14.2 (n = 21) | 68.4 ± 10.3 (n = 23)* | 68.7 ± 7.8 (n = 22) | 62.9 ± 11.43 (n = 17)† |
Data are means ± SD unless otherwise indicated. Body composition was gathered by NMR. Comparisons made with t test between genotypes (within sex).
†P < 0.1;
*P < 0.05 compared with Ghsr+/+.