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. 2019 Aug 14;68(9):1730–1746. doi: 10.2337/db18-0927

Figure 5.

Figure 5

Altering BCAA intake affects IR in ob/ob mice. ob/ob mice were fed an NPD (20% protein by weight) or an LPD (6% protein by weight) for 4 weeks beginning at 10 weeks of age. For the BCAA group (LPD + BCAA), supplementation of BCAAs in drinking water (3 mg/mL) was started after mice had eaten the LPD for 2 weeks and lasted 2 weeks. We analyzed fasting plasma levels of BCAAs and metabolites (n = 8 mice; *P < 0.05 vs. NPD; &P < 0.05 vs. LPD) (A), glucose tolerance test results (n = 6–13 mice; **P < 0.01, LPD vs. NPD; &P < 0.05, LPD vs. LPD + BCAA) (B), insulin tolerance test results (n = 6 mice in each group; *P < 0.05, ***P < 0.001, LPD vs. NPD; &P < 0.05, LPD vs. LPD + BCAA) (C), fasting plasma insulin levels (n = 8–12 mice; *P < 0.05; &P < 0.05) (D), and body weight (n = 14 mice in each group; **P < 0.01).