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. 2019 Aug 12;146(15):dev175497. doi: 10.1242/dev.175497

Fig. 8.

Fig. 8.

Apical identity and morphogenesis in the photoreceptor. (A) Defining the apical pole of the cell. Active Cdc42 is detected at the apical membrane (this work) and is required for Baz-Par6-aPKC localization at the membrane (this work and Walther and Pichaud, 2010). This requirement is indicated with the grey arrow from Cdc42 towards Baz and Baz-Par6-aPKC. The nature of the requirement for Cdc42 in promoting Baz membrane localization is not known. In this model, Baz loads Par6-aPKC (Par complex) at the membrane. Par6-aPKC exchanges from Baz to Cdc42 between the Par complex and the ternary Cdc42-Par6-aPKC complex. (B) Epithelial morphogenesis. Cdc42 binding to Par6 promotes the retention of Par6-aPKC by Crb (this work). In this model, apical delivery of Crb coincides with active Cdc42 at the apical pole of the cell. Binding of Par6 to Crb promotes the stabilization of Crb at the membrane and apical retention of Par6-aPKC. Apical accumulation of Crb is required for photoreceptor morphogenesis (Izaddoost et al., 2002; Pellikka et al., 2002).