Table 1.
Summary of the results of the MR image analysis.
| Control | Sham | s-mTBI | r-mTBI | s-sTBI | ||
|---|---|---|---|---|---|---|
| Animals/group | week 1 | 3 | 3 | 6 | 5 | - |
| week 4 | - | - | 7 (6)* | 6 | 4 | |
| Ventricles volume/mm3 | week 1 | no MRI | no MRI | C: 6.8±0.4 I: 12±6 (p=0.036) |
C: 6.0±1.2 I: 6.7±1.3 (p=0.041) |
no MRI |
| week 4 | C: 7.78±0.11 I: 8.0±0.6 (p=0.35) |
C: 10±3 I: 7.8±0.9 (p=0.25) |
C: 10±4 I: 17±8 (p=0.025) |
C: 10±3 I: 14±6 (p=0.012) |
C: 20±7 I: 34±15 (p=0.022) |
|
| paired t-test | - | - | C: p=0.064 I: p=0.049 |
C: p=0.12 I: p=0.030 |
- | |
| Hemorrhages, # of animals | week 1 | no MRI | no MRI | C: 0 I: 6 (100%) |
C: 0 I: 6 (100%) |
- |
| week 4 | C: 0 I: 0 |
C: 0 I: 0 |
C: 0 I: 7 (100%) |
C: 0 I: 6 (100%) |
C: 0 I: 4 (100%) |
|
| Hemorrhages, volume/mm3 | week 1 | no MRI | no MRI | - | - | no MRI |
| week 4 | - | - | 1.0±0.5 | 2.0±0.8 | 0.94±1.9 | |
| Calcifications, # of animals | week 1 | no MRI | no MRI | 0 | 0 | no MRI |
| week 4 | 0 | 0 | 3 (50%) | 5 (83%) | 1 (25%) | |
| Calcifications, volume/mm3 | week 1 | no MRI | no MRI | - | - | - |
| week 4 | - | - | 0.04±0.04 | 0.3±0.3 | 0.12±0.00 | |
| paired t-test | - | - | p=0.13 | p=0.041 | - | |
| calcifications, susceptibility/ppb | week 1 | no MRI | no MRI | - | - | - |
| week 4 | - | - | −56±30 | −56±19 | −60.4±0.0 |
Values are reported as mean ± standard deviation. “I” and “C” denote ipsilateral (right) and contralateral (left) hemisphere, respectively. “# of animals” is the number of animals in which hemorrhage/calcification was observed. Group averages of calcification volume were calculated using only animals in which calcification was found. This implies that the stated values represent the average volume of identified lesions. The paired t-test used on a volume of 0 mm3 if no lesion was found at week 1.
*
The susceptibility map of one of the s-mTBI animals at week five could not be analyzed due to motion artifacts.