Figure 6:

(A ) Concentration dependent increases in flare area after intradermal injection of several concentrations of 48–80, morphine or DMT-DALDA in anesthetized dogs. Regression analysis of log data indicated all slopes were statistically significant ( (p < 0.0001) and not different from each other (p>0.05). Concentrations of the three drugs producing a fixed flare effect were determined and found to have overlapping 95% confidence intervals, e.g. were not different. (see Table 1) (B) Figure shows the flare size observed after a fixed dose of 48–80,morphine or DMT-DALDA was prevented by pretreatment with cromolyn (10 mg/kg, IM), but not naltrexone (1 mg/kg, IM) (2 way ANOVA, Dunnetts post hoc ****; p<0.0001. )