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. 2019 Aug 21;4(4):e00206-19. doi: 10.1128/mSphere.00206-19

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Copyright © 2019 Weil et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 2 — IL23 is expressed and secreted in response to stimulation of differentiated THP-1 cells with live toxigenic V. cholerae O1. IL23 expression (A) and secretion (B) were measured in response to recombinant CT, CTB, live V. cholerae N16961 (Live), live V. cholerae ΔctxAB JBK70 (Live ΔVC), heat-inactivated wild-type V. cholerae N16961 (Inactivated), heat-inactivated wild-type V. cholerae N16961 with CT (Inactivated VC + CT), heat-inactivated wild-type V. cholerae N16961 with CTB (Inactivated VC + CTB), and live V. cholerae ΔctxAB JBK70 with CT (Live ΔVC + CT). Each point represents the mean of results from three technical replicates from a single experiment, while the horizontal bars represent mean values across multiple biological replications of the cell culture stimulation experiment. Error bars represent standard errors of the means. Expression was determined by qRT-PCR, and IL-23 secretion was determined by ELISA using cells/supernatants collected after 24 h of stimulation. ***, P < 0.001; **, P < 0.01; *, P < 0.05 (by paired nonparametric testing).