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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Neuropharmacology. 2019 Jun 21;157:107672. doi: 10.1016/j.neuropharm.2019.107672

Figure 6. Disrupting GRIP1 in the PFC augments glutamate transmission in the PFC and nucleus accumbens.

Figure 6.

Quantification of sEPSC amplitude reveals an increase in prefrontal GRIP1 knockout mice compared to GFP controls [a; t(15)=3.24, **p<0.01; n=15–20]. No differences were seen between the groups in sEPSC frequency (b; n=15–19). Prefrontal GRIP1 knockout led to a decrease in the paired-pulse ratio (40ms IPI) in both naïve and cocaine-experienced mice [c; F(1,33)=4.35, p=0.04; n=12–13]. Bars represent average ± SEM.