Table 1.

Raw data for behavioral tests separated by sex. No significant effects of sex were seen in any of the behavioral measured and therefore the data were collapsed across sex for all analyses. There was a significant interaction between sex and knockout on the number of food pellets earned on day 10 but the pairwise comparisons did not reveal any significant differences.

Behavioral Variable	GFP Control Males	GFP Control Females	GRIP KD Males	GRIP KD Females	Effect of Sex	Interaction
Food Pellets D10	45±2 n=17	49±0.8 n=22	48±1 n=21	46 ±1 n=25	F(1,81) = 0.35, p = 0.56	F(1,81) = 4.30, p = 0.04*
Food Responses D10	2911±559 n=17	2111±314 n=22	2173±603 n=21	2181±284 n=25	F(1,81) = 0.82, p = 0.37	F(1,81) = 0.85, p = 0.36
Food PR	2191±419 n=11	1311±261 n=13	1384±264 n=12	2273±644 n=14	F(1,46) < 0.01, p = 0.99	F(1,46) = 3.88, p = 0.06
Food RI	2462±1410 n=5	3182±1203 n=7	1274±222 n=7	3219±1100 n=7	F(1,22) = 1.62, p = 0.22	F(1,22) = 0.34, p = 0.56
Cocaine Infusions D10	42±3 n=15	40±2 n=19	36±5 n=10	37±4 n=17	F(1,58) < 0.01, p = 0.96	F(1,58) = 0.14, p = 0.71
Cocaine Responses D10	356±71 n=15	316±59 n=19	256±55 n=10	515±147 n=17	F(1,58) = 0.99, p = 0.32	F(1,58) = 1.84, p = 0.18
Cocaine PR	183±64 n=10	144±34 n=13	435±190 n=6	369±161 n=11	F(1,37) = 0.19, p = 0.67	F(1,37) = 0.01, p = 0.91
Cocaine RI	307±56 n=10	387±98 n=10	668±344 n=5	779±301 n=9	F(1,30) = 0.21, p = 0.65	F(1,30) < 0.01, p = 0.94

^*p<.05.