Table 3.
Liver tests.
| Changes from baseline (Adjusted means [95% CI]) |
0·1 mg (N = 10) |
1 mg (N = 11) |
10 mg (N = 11) |
|---|---|---|---|
| ALAT (U/L) | 0·0 [−14·0, 14·0] P = 0·999 |
−4·1 [−16·8, 8·7] P = 0·497 |
3·4 [−9·5,16·3] P = 0·568 |
| ALP (U/L) | 9 [−23, 40] P = 0·556 |
−33 [−63, −4] P = 0·032 |
−16 [−46,14] P = 0·255 |
| Total Bilirubin (μmol/L) | −0·2 [−1·8,1·5] P = 0·838 |
−0·3 [−1·8,1·3] P = 0·718 |
−1·9 [−3·4, −0·5] P = 0·016 |
| Conjugated Bilirubin (μmol/L) | 0·4 [−0·4, 1·2] P = 0·287 |
−0·2 [−1·0, 0·5] P = 0·515 |
−0·4 [−1·1, 0·4] P = 0·358 |
| Unconjugated Bilirubin (μmol/L) | 0·2 [−1·0, 1·4] P = 0·710 |
0·2 [−1·0, 1·3] P = 0·732 |
−1·3 [−2·4, 0·1] P = 0·035 |
| INR | −0·02 [−0·09, 0·06] P = 0·682 |
0·07[−0·01, 0·14] P = 0·080 |
−0·00 [−0·08,0·07] P = 0·925 |
| Plasma Albumin (g/L) | −1·2 [−3·1, 0·6] P = 0·173 |
−2·1 [−3·9, −0·4] P = 0·023 |
−1·2 [−3·0, 0·6] P = 0·165 |
ALAT = Alanine Transaminase; ALP = Alkaline Phosphatase; INR = International Normalised Ratio; N = number of patients in full analysis set.