Fig. 4.

Significantly modulated individual SPMs during STEMI.

Plasma from healthy volunteers (n = 10) and patients with stable CAD (n = 10) and STEMI (n = 15) were collected after MI onset. Repeated samples were drawn from STEMI patients. LM were obtained using LC-MS/MS. (a) Quantification of PD1, 10S,17S-diHDA, (b) PD2_{n-3 DPA}, 10S,17SdiHDPA, and (c) RvD5_{n-3 DPA}. Results are expressed as pg/ml and mean ± SEM *p < 0·05, **p < 0·01, ***p < 0·001 vs. STEMI baseline. ^#p < 0·05, ^##p < 0·01, ^###p < 0·001 for repeated measures ANOVA for STEMI-baseline, day 1, and day 8. LM, lipid mediators.