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. 2019 Jun 19;79(10):1147–1156. doi: 10.1007/s40265-019-01152-7
IV PEGylated rFVIII designed to prolong FVIII activity; has a longer terminal half-life and greater exposure than non-PEGylated FVIII and rFVIII products
Prophylaxis reduced spontaneous and joint ABRs in previously treated adults and adolescents
Effective in treating bleeding episodes and for perioperative management
Generally well tolerated with no confirmed cases of anti-FVIII inhibitor development