Table 1. Estimated posterior median fitness and 95% CI for the Ebola GP mutants relative to the Makona genotype.

Genotype	Sample freq	Base model	Model + geo effects	Effect in cell culture
Makona	0.036	1.00	1.00	Reference genotype
A82V	0.720	1.05 (1.04–1.07)	1.26 (1.19–1.35)	Increases infectivity 2X
P330S	0.002	0.98 (0.82–1.14)	1.11 (0.96–1.24)	Decreases infectivity
P330S+N107D+G480D	0.037	1.04 (0.98–1.12)	1.27 (1.16–1.39)	Increases infectivity > 2X
A82V+R410S	0.044	1.09 (1.00–1.18)	1.31 (1.17–1.45)	No or small effect
A82V+R410S+K439E	0.035	1.14 (1.01–1.26)	1.36 (1.20–1.54)	Increases infectivity 2-3X
A82V+R29K	0.019	1.06 (0.93–1.19)	1.27 (1.10–1.45)	Increases infectivity 2-3X
A82V+T230A	0.026	1.03 (0.93–1.11)	1.23 (1.10–1.37)	Increases infectivity 2-3X
A82V+I371V	0.067	1.03 (0.98–1.09)	1.24 (1.14–1.35)	Increases infectivity 2-3X