Skip to main content
NIHPA Author Manuscripts logoLink to NIHPA Author Manuscripts
. Author manuscript; available in PMC: 2020 Sep 1.
Published in final edited form as: Prev Med. 2019 Jul 16;126:105778. doi: 10.1016/j.ypmed.2019.105778

Receipt of direct tobacco mail \ email coupons and coupon redemption: demographic and socioeconomic disparities among adult smokers in the United States

Amira Osman a,b, Tara Queen b, Kelvin Choi c, Adam O Goldstein b,d
PMCID: PMC6717625  NIHMSID: NIHMS1535244  PMID: 31323282

Abstract

A key marketing strategy used by tobacco companies to lower tobacco product prices is the distribution of tobacco coupons via direct marketing channels such as mail or email. We analyzed data on adult smokers from Wave 1 of the Population Assessment of Tobacco and Health (PATH) Study (n=10,994) to examine the prevalence and correlates of coupon receipt via both channels, and associations with cigarette coupon redemption. Overall, 22% and 32% of smokers received tobacco coupons via email and mail, respectively, and 22% redeemed cigarette coupons. White, 25-44 year old, female, sexual minority, and more nicotine dependent smokers were more likely to receive coupons via both channels and to redeem coupons, as were smokers with mid-levels education (GED to associate degree) and those unable to pay important bills (OR email receipt=1.37, 95% CI 1.22-1.54; OR mail receipt=1.38, 95% CI 1.24-1.55; and OR coupon redemption=1.44, 95% CI 1.26-1.64). Smokers who received coupons via mail only or via both channels, had three times (OR=2.97, 95% CI 2.31-3.83) and five times (OR=4.56, 95% CI 3.61-5.76) higher odds to redeem cigarette coupons compared to those who received them via email only. Major demographic and socioeconomic disparities exist in receipt and redemption of direct email\mail tobacco coupons among US smokers. Cigarette coupons received via direct mail are more likely to be redeemed than coupons received via email. Restrictions on tobacco coupon redemption, implemented jointly with increasing access to affordable cessation resources, may incentivize smokers vulnerable to tobacco marketing tactics to quit.

Keywords: Tobacco coupons, Tobacco price promotions, coupon receipt, coupon redemption, direct mail marketing

BACKGROUND

High cigarette prices are an effective measure to curtail smoking behavior (Chaloupka et al., 2011; Jha and Chaloupka, 2000). Cigarette price increases are associated with lower odds of smoking initiation, lower cigarette consumption (Cavazos-Rehg et al., 2014; Gallus et al., 2006) and increased smoking cessation (Stevens et al., 2017). Tobacco industry marketing efforts, however, may undermine the public health effects of upholding high cigarette prices. Tobacco companies’ advertising and promotional expenditures reach an estimated $8 billion annually, of which the largest single category is price discounts, primarily for cigarettes (Federal Trade Commission, 2017). In the wake of marketing restrictions on tobacco products following the 1998 Master Settlement Agreement (MSA) (Master Settlement Agreement, 1998), tobacco companies have shifted focus towards direct marketing channels to reach consumers directly through the mail or the web (Brock et al., 2015; Czaplewski and Olson, 2003; Lewis et al., 2004b; Seidenberg and Jo, 2017). Despite all tobacco control measures taken thus far, the tobacco industry continues to show an interest in establishing reward programs and promotions for their combustible products (Kress, 2018), and efforts to push tobacco coupons through other direct digital channels such as apps (Seidenberg and Jo, 2017).

The use of direct marketing channels by the tobacco industry is particularly worrying as it allows companies to connect directly with smokers and to personalize promotional materials (Lewis and Ling, 2016). Moreover, tobacco coupons are a form of product advertising through which tobacco companies cultivate positive industry perceptions and brand loyalty (Lewis and Ling, 2016). Evidence indicates that tobacco companies have extensive direct mailing lists, used to distribute coupons and giveaways tailored to the consumer’s brand and lifestyle preferences (Czaplewski and Olson, 2003; Lewis et al., 2004b). Whereas direct mail delivery of coupons has long been used by the tobacco industry (Lewis and Ling, 2016), direct email delivery is evolving and no study to date has estimated it’s prevalence or correlates.

Marketing strategies that offer discounts for tobacco products impact mainly price sensitive consumers who seek out ways to reduce their cigarette expenditures (Hyland et al., 2005). As such, particularly following tax increases, price sensitive smokers engage in a variety of price-minimization strategies made available to them by the tobacco industry, including the redemption of coupons (Choi and Boyle, 2018; Hyland et al., 2005; Xu et al., 2013). In the US, approximately 12% of adult nonsmokers, and 35% to 49% of adult smokers receive direct marketing coupons and price promotions, primarily for cigarettes (Choi et al., 2013; Choi et al., 2018a; Choi et al., 2018b; Lewis et al., 2004a), and nearly 20% to 40% of adults smokers redeem coupons when purchasing tobacco products (Choi et al., 2013; Lewis et al., 2004a; Lewis et al., 2015; Xu et al., 2013). Rates of coupon redemption for cigarettes are staggering high at 70%-80% among adult smokers who receive direct mail from tobacco companies (Choi et al., 2013; Lewis et al., 2015). These strategies may circumvent price and tax increases of tobacco products, undermine the effect of price-based tobacco control measures, and contribute to sustaining or widening tobacco use disparities in the U.S. and worldwide. Indeed, evidence points to negative effects of tobacco coupons on smoking behavior of both smokers and non-smokers (Choi and Forster, 2014; Choi et al., 2018a; Soneji et al., 2014). As such, smokers who use tobacco coupons hold more positive views of the tobacco industry (Choi et al., 2013) and are less likely to quit (Choi et al., 2019; Choi and Forster, 2014; Choi et al., 2018a). Among youth and adult non-smokers, exposure to tobacco coupons is associated with initiation and progression to smoking (Choi et al., 2019; Choi and Forster, 2014; Choi et al., 2018a).

Despite this evidence, the issue of direct marketing price promotions remains understudied. First, only three studies used nationally representative data on adults (Choi et al., 2019; Choi et al., 2018a; Xu et al., 2013) and only one study used nationally representative data on youth (Rose et al., 2018) to examine correlates of receiving tobacco coupons. None of these studies, however, examined the prevalence or correlates of coupon redemption. Second, studies on tobacco price promotions reporting characteristics associated with direct mail coupon receipt neglect to consider characteristics associated with other channels of receipt (i.e., email). Lastly, no study has examined how different channels of coupon receipt relate to coupon redemption. In this study, we use nationally representative data on US adult smokers to examine characteristics of smokers who receive and redeem tobacco coupons. Building on previous research, we consider a broader set of socioeconomic indicators and examine their association to coupon receipt via two direct marketing channels (email vs. mail), and to coupon redemption, and how channel of coupon receipt (email, mail, or both) relates to coupon redemption when buying cigarettes.

METHODS

Sample and data

We analyzed data from Wave 1 of the Population Assessment of Tobacco and Health (PATH) Study, a nationally representative cohort of youth and adults in the US, designed to inform FDA’s regulatory activities under the Family Smoking Prevention and Tobacco Control Act (FSPTCA). Using a four-stage stratified sampling design, the study sampled 32,320 participating adults (response rate 74%), aged 18 or older, of which 11,402 were current smokers (smoked 100 cigarettes in their lifetime and smoked somedays or every day in the past month). Data were collected in 2013-2014, using audio computer-assisted self-interview. Adult respondents were paid $35 for participation (United States Department of Health and Human Services et al., 2017b).

Measures

Receipt of tobacco coupons via email or mail.

Participants were asked whether in the past 6 months they have received promotions or coupons for cigarettes or tobacco products “in an e-mail message” or “in the mail” (No, Yes).

Redemption of tobacco coupons when purchasing cigarettes.

Smokers were asked whether in the past month they had used a coupon when buying cigarettes. (No, Yes).

Demographic variables.

Age was categorize into young adults (18-24), two age groups of middle age adults (24-44 and 45-64), and older adults (65 or older). Other demographics included sex, Hispanic origin, race (White, Black, or other race), self-identified sexual orientation (sexual minority vs. heterosexual) and census region (Northeast, Midwest, South, or West).

Economic variables

Ability to pay important bills.

One item assessed financial difficulties by asking participants “In the past 30 days, because of a shortage of money, were you unable to pay important bills on time, such as rent, electricity or telephone bills?” (No, Yes).

Poverty status.

Using data on annual household income and number of household members, participants were classified to be below (<100% of poverty line), at or near (100–199% of poverty line), or at or above twice (≥200% of poverty line) the poverty level. Respondents with missing data on household income were coded as a separate group of “Unknown poverty status”. More details on this variable are available elsewhere (United States Department of Health and Human Services et al., 2017a).

Employment status.

Participants indicated whether they currently: work full-time, part-time, or do not work for pay. The latter group was asked “Are you currently: looking for paid work, a student, a homemaker or caregiver not looking for paid work, retired, unable to work for health reasons or due to other reasons”. Based on these questions, participants were classified as “employed full or part time”, “unemployed or unable to work”, and “not looking for paid job” (including students, homemakers, and retirees).

Educational attainment.

Participants indicated the highest level of school they completed and were coded as “less than high school”, “GED or high school graduate”, “some college but no degree, or associate degree”, and “bachelor’s degree or higher”.

Smoking related variables.

Sixteen items measured tobacco dependence across users of different tobacco products. The psychometric properties of this instrument have been reported elsewhere (Strong et al., 2017). Responses across items were summed ranging from 0 to 61, with higher numbers indicating greater level of tobacco dependence. Then, a three-level tobacco dependence variable was created using tertiles as the cut off points (0-20=low, 21-37=moderate, 38-61=high). Past quit attempt was assessed by asking participants if they had tried to quit using tobacco in the past 12 months. Smokers were coded as those who have tried to quit completely, those who have cut back or reduced the amount they smoke, and those who have not tried to quit. Overall opinion of tobacco use was assessed using one item that classified participants into smokers who thought positively or negatively of tobacco use, and those whose opinion was neither negative nor positive.

Statistical analysis

All analyses were conducted using Stata 13 (Statacorp, 2013). Missing data on study variables, except poverty status, were small (<1.8%). Respondents with missing data on all variables, except poverty status, were excluded from the analyses. About 7% of smokers (n=769) had missing data on poverty status and were coded separately (Unknown poverty status). The final analytic sample included 10,994 smokers. Unadjusted and adjusted main effect logistic regression models were estimated to examine associations between the independent variables (i.e., demographic, economic, and smoking related variables) and each of three outcomes (1) coupon receipt via email, (2) coupons receipt via mail, and (3) coupon redemption when purchasing cigarettes. Since women are generally more likely to use coupons; and from an intersectionality perspective, we re-estimated all aforementioned models testing for a gender by race interaction effect to examine whether the intersection of gender and race confers higher risk for tobacco coupon use and redemption.

Next, we further restricted our sample to smokers who received direct marketing coupons in the past 6 months (n=4,043), and participants were classified into those who received coupons (1) via email only, (2) via mail only, and (3) via both email and mail. Logistic regression models estimated the association between channel of coupon receipt and coupon redemption adjusting for all other covariates. In all analyses, balanced repeated replication weights were utilized with Fay’s correction (shrinkage factor set at 0.3) to account for PATH study design, oversampling of tobacco users, and to ensure the findings were representative of US non-institutionalized adults (United States Department of Health and Human Services et al., 2017b).

As a sensitivity analysis and to test the robustness of the results, all models were re-estimated again excluding from the sample participants who had missing data on poverty status (n=769) with an analytic sample of n=10,225 smokers. Results from this re-analysis were similar in terms of direction, magnitude, and significance of associations to the results reported in the Tables and would not have changed our conclusions.

RESULTS

Sample characteristics

Half the sample were male (53%) with a majority non-Hispanic (87%) and White (76%) (Table 1). Twenty-eight percent were unable to pay important bills in the past month, and 38% lived below the poverty line. The majority of smokers (61%) were employed. Overall, 37% reported receiving tobacco coupons through direct-to-consumer channels in the past 6 months: 22% via email and 32% via mail (5% via email only, 15% via mail only, and 17% via both channels), and 22% reported redeeming coupons when buying cigarettes.

Table 1.

Sample Characteristics of Smokers, PATH study, Wave 1 (2013-2014), n=10,994

n %
Age 18-24 2,410 22
25-44 4,503 41
45-64 3,400 31
65 or older 681 6
Sex Male 5,785 53
Female 5,209 47
Hispanic origin No 9,614 87
Yes 1,380 13
Race White 8,398 76
Black 1,545 14
Other race 1,051 10
Sexual orientation Heterosexual 10,068 92
Self-identified sexual minority 926 8
Census region Northeast 1,651 15
Midwest 2,988 27
South 4,312 39
West 2,043 19
Able to pay important bills Yes 7,961 72
No 3,033 28
Poverty status Below poverty line 4,147 38
At or near poverty line 2,776 25
At or above twice poverty line 3,302 30
Unknown 769 7
Employment status Unemployed or unable to work 2,924 27
Not looking for paid work 1,315 12
Employed part or full time 6,755 61
Education Less than high school 1,823 17
GED or high school 4,050 37
Some college or associate degree 3,956 36
Bachelor’s degree or higher 1,165 10
Nicotine dependence Low 3,584 33
Moderate 3,575 32
High 3,835 35
Past quit attempts Have not tried to quit 3,730 34
Tried cutting back 4,662 42
Have tried to quit completely 2,602 24
Overall opinion of using tobacco Negative 1,425 13
Neither positive nor negative 5,033 46
Positive 4,536 41
Receipt of direct marketing coupons via email No 8,607 78
Yes 2,387 22
Receipt of direct marketing coupons via mail No 7,476 68
Yes 3,318 32
Coupon redemption when purchasing cigarettes No 8,525 78
Yes 2,469 22

Note. Data are unweighted.

Correlates of coupon receipt via email

Smokers aged 25-44 had higher odds to receive tobacco coupons via email compared to other age groups, as were females (aOR 1.15, 95% Cl 1.04, 1.28) and sexual minority smokers (aOR 1.25, 95% Cl 1.05, 1.49) compared to males and heterosexuals. There were no statistically significant racial differences in receipt of tobacco coupons via email (Table 2). Smokers who reported difficulty paying bills had significantly higher odds to receive coupons via email (aOR=1.37, 95% Cl 1.22, 1.54) than those who did not report such difficulty. Poverty status and employment status were not significantly associated with receipt of coupons via email in the adjusted model. Higher nicotine dependence was significantly associated with higher odds to receive tobacco coupons via email (aOR 1.45, 95% CI 1.28, 1.65; and aOR 1.77, 95% CI 1.52, 2.04 for moderate and high tobacco dependence, respectively).

Table 2.

Unadjusted and adjusted associations between demographic and socioeconomic variables and tobacco coupon receipt via email and mail among U.S adult smokers, PATH study (n=10,994), weighted estimates

Receipt of tobacco industry coupons via email Receipt of tobacco industry coupons via mail
Independent variables Unadjusted Adjusted Unadjusted Adjusted
n % OR (95% CI) aOR (95% CI) n % OR (95% CI) aOR (95% CI)
Age
 18-24 443 18 0.66 (0.58, 0.76) 0.68 (0.59, 0.78) 548 22 0.47 (0.41, 0.53) 0.48 (0.42, 0.55)
 25-44 1,142 25 1.00 1.00 1,757 39 1.00 1.00
 45-64 727 21 0.80 (0.73, 0.90) 0.82 (0.73, 0.91) 1,070 31 0.72 (0.64, 0.81) 0.71 (0.63, 0.79)
 65 or older 75 11 0.35 (0.27, 0.45) 0.42 (0.32, 0.55) 143 21 0.39 (0.32, 0.47) 0.45 (0.35, 0.56)
Sex
 Male 1,143 20 1.00 1.00 1,610 28 1.00 1.00
 Female 1,244 24 1.23 (1.12, 1.36) 1.15 (1.04, 1.28) 1,908 36 1.44 (1.32, 1.57) 1.38 (1.25, 1.52)
Hispanic origin
 No 2,112 22 1.00 1.00 3,213 33 1.00 1.00
 Yes 275 20 0.85 (0.73, 0.99) 0.95 (0.79, 1.13) 305 22 0.56 (0.47, 0.67) 0.64 (0.53, 0.78)
Race
 White 1,837 22 1.00 1.00 2,771 33 1.00 1.00
 Black 314 20 0.90 (0.78, 1.04) 0.89 (0.77, 1.03) 430 28 0.77 (0.66, 0.89) 0.73 (0.62, 0.88)
 Other 236 22 0.88 (0.74, 1.05) 0.91 (0.76, 1.09) 317 30 0.72 (0.60, 0.87) 0.84 (0.70, 1.02)
Sexual orientation
 Heterosexual 2,146 21 1.00 1.00 3,183 32 1.00 1.00
 Self-identified sexual minority 241 26 1.38 (1.18, 1.62) 1.25 (1.05, 1.49) 335 36 1.26 (1.09, 1.47) 1.18 (1.01, 1.37)
Census region
 Northeast 321 19 1.00 1.00 493 29 1.00 1.00
 Midwest 703 23 1.27 (1.07, 1.51) 1.25 (1.05, 1.49) 1,105 37 1.45 (1.23, 1.72) 1.39 (1.17, 1.64)
 South 933 22 1.19 (1.01, 1.39) 1.16 (0.98, 1.37) 1,366 31 1.16 (0.98, 1.37) 1.12 (0.94, 1.33)
 West 430 21 1.15 (0.94, 1.39) 1.17 (0.96, 1.42) 554 27 0.95 (0.81, 1.11) 1.02 (0.86, 1.20)
Able to pay important bills
 Yes 1,539 19 1.00 1.00 2,317 29 1.00 1.00
 No 848 28 1.59 (1.42, 1.76) 1.37 (1.22, 1.54) 1,201 40 1.60 (1.44, 1.77) 1.38 (1.24, 1.55)
Poverty status
 Unknown poverty status 111 14 0.68 (0.54, 0.87) 0.76 (0.59, 0.97) 176 22 0.70 (0.58, 0.83) 0.78 (0.65, 0.94)
 Below poverty line 963 23 1.18 (1.06, 1.32) 1.05 (0.92, 1.21) 1,364 33 1.15 (1.04, 1.28) 1.08 (0.94, 1.23)
 At or near poverty line 639 23 1.18 (1.03, 1.35) 1.11 (0.96, 1.29) 949 34 1.19 (1.06, 1.33) 1.13 (0.99, 1.28)
 At or above twice poverty line 674 20 1.00 1.00 1,029 31 1.00 1.00
Employment status
 Unemployed or unable to work 676 23 1.12 (1.00, 1.25) 1.10 (0.97, 1.24) 962 33 1.01 (0.91, 1.12) 0.94 (0.84, 1.05)
 Not looking for paid work 229 17 0.69 (0.57, 0.82) 0.88 (0.73, 1.07) 361 27 0.70 (0.59, 0.82) 0.81 (0.68, 0.97)
 Employed part or full time 1.482 22 1.00 1.00 2,195 32 1.00 1.00
Education
 Less titan high school 343 19 0.83 (0.72, 0.95) 0.82 (0.72, 0.94) 525 29 0.85 (0.73, 0.98) 0.90 (0.77, 1.05)
 GED or high school 851 21 1.00 1.00 1,305 32 1.00 1.00
 Some college or associate degree 965 24 1.16 (1.03, 1.31) 1.14 (1.01, 1.30) 1,360 34 1.07 (0.96, 1.17) 1.02 (0.92, 1.13)
 Bachelor’s or advanced degree 228 19 0.87 (0.71, 1.08) 0.99 (0.78, 1.25) 328 28 0.75 (0.62, 0.89) 0.81 (0.66, 0.99)
Nicotine dependence
Low 574 16 1.00 1.00 816 23 1.00 1.00
 Moderate 789 22 1.51 (1.33, 1.71) 1.45 (1.28, 1.65) 1,218 34 1.77 (1.57, 2.00) 1.63 (1.43, 1.86)
 High 1,024 27 1.85 (1.62, 2.12) 1.77 (1.52, 2.04) 1,484 39 2.13 (1.89, 2.41) 1.91 (1.68, 2.17)
Past quit attempts
 Have not tried to quit 748 20 0.84 (0.74, 0.96) 0.82 (0.72, 0.95) 1,140 30 0.92 (0.82, 1.03) 0.86 (0.77, 0.98)
 Tried cutting back 1,057 22 1.00 (0.89, 1.13) 1.03 (0.91, 1.15) 1,554 33 1.07 (0.96, 1.20) 1.08 (0.96, 1.20)
 Have tried to quit completely 582 22 1.00 1.00 824 32 1.00 1.00
Overall opinion of using tobacco
 Negative 979 21 1.00 1.00 1,428 31 1.00 1.00
 Neither negative nor positive 1,103 22 1.04 (0.93, 1.16) 1.12 (0.99, 1.26) 1,653 33 1.09 (0.98, 1.21) 1.17 (1.05, 1.31)
 Positive 305 21 1.03 (0.90, 1.18) 1.15 (1.01, 1.32) 437 31 0.97 (0.85, 1.12) 1.08 (0.94, 1.25)

Note, n’s and % of adult smokers across predictor categories who received tobacco coupons via mail or email in the past 6 months.

Correlates of coupon receipt via mail

Smokers aged 25-44 had higher odds to receive coupons via mail than other age groups (Table 2). Females, non-Hispanic, White, and sexual minority smokers had higher odds to receive tobacco coupons via mail compared to males, Hispanics, Black, and heterosexual smokers. Coupon receipt via mail was also significantly higher among smokers who reported difficulty paying important bills (aOR=1.38, 95% CI 1.24, 1.55) compared to those who did not report such difficulty, and lower among smokers with a bachelor degree education or higher (aOR=0.81, 95% CI 0.66, 0.99) compared to those with GED or high school education. Tobacco dependence was positively associated with mail coupon receipt (aOR 1.63, 95% CI 1.43, 1.86, and aOR 1.91, 95% CI 1.68, 2.17 for moderate and high tobacco dependence, respectively). Smokers who expressed indifferent opinion of tobacco (neither negative nor positive) had higher odds of mail coupon receipt than smokers with a negative view of tobacco use (aOR 1.17, 95% CI 1.05, 1.31).

Correlates of coupon redemption for purchasing cigarettes

Smokers aged 25-44, females, non-Hispanic, White, and sexual minority smokers had significantly higher odds to redeem coupons when buying cigarettes than all other age groups, males, Hispanics, racial minorities (Blacks and other race), and heterosexual smokers (Table 3). Smokers who reported difficulty paying bills (aOR=1.44, 95% CI 1.26, 1.64) had significantly higher odds to redeem these coupons than those who did not report such difficulty. Poverty and employment status were not significantly associated with coupon redemption. Compared to smokers with GED or high school diploma, smokers with less than high school education (aOR=0.76, 95% CI 0.65, 0.88) and those with a bachelor degree or higher (aOR 0.65, 95% CI 0.53, 0.80) had lower odds to redeem coupons when purchasing cigarettes.

Table 3.

Unadjusted and adjusted associations between demographic and socioeconomic variables and coupon redemption in the purchase of cigarettes among U.S adult smokers, PATH study (n=10,994), weighted estimates

Redemption of Tobacco Coupons
Independent variables Unadjusted Adjusted
n % OR (95% CI) aOR (95% CI)
Age
 18-24 469 19 0.65 (0.57, 0.74) 0.68 (0.59, 0.78)
 25-44 1,211 26 1.00 1.00
 45-64 717 21 0.72 (0.63, 0.82) 0.71 (0.62, 0.81)
 65 or older 72 10 0.30 (0.22, 0.41) 0.34 (0.25, 0.48)
Sex
 Male 1,154 20 1.00 1.00
 Female 1,315 25 1.30 (1.17, 1.45) 1.23 (1.09, 1.40)
Hispanic origin
 No 2,263 23 1.00 1.00
 Yes 206 15 0.58 (0.47, 0.70) 0.69 (0.56, 0.85)
Race
 White 1,997 24 1.00 1.00
 Black 286 18 0.73 (0.62, 0.88) 0.69 (0.58, 0.83)
 Other 186 18 0.57 (0.46, 0.71) 0.66 (0.53, 0.82)
Sexual orientation
 Heterosexual 2,216 22 1.00 1.00
 Self-identified sexual minority 253 27 1.30 (1.12, 1.51) 1.18 (1.01, 1.39)
Census region
 Northeast 306 18 1.00 1.00
 Midwest 812 27 1.73 (1.36, 2.19) 1.65 (1.30, 2.08)
 South 981 23 1.36 (1.06, 1.75) 1.29 (1.02, 1.65)
 West 370 18 1.00 (0.75, 1.32) 1.09 (0.82, 1.43)
Able to pay important bills
 Yes 1,597 20 1.00 1.00
 No 872 29 1.64 (1.45, 1.85) 1.44 (1.26, 1.64)
Poverty status
 Unknown poverty status 137 18 0.92 (0.71, 1.18) 0.99 (0.75, 1.32)
 Below poverty line 1,004 24 1.31 (1.18, 1.46) 1.11 (0.95, 1.31)
 At or near poverty line 657 23 1.20 (1.06, 1.38) 1.08 (0.93, 1.27)
 At or above twice poverty line 671 20 1.00 1.00
Employment status
 Unemployed or unable to work 689 24 1.07 (0.95, 1.20) 1.00 (0.87, 1.14)
 Not looking for paid work 233 18 0.66 (0.55, 0.79) 0.84 (0.69, 1.04)
 Employed part or full time 1,547 23 1.00 1.00
Education
 Less than high school 349 19 0.73 (0.63, 0.85) 0.76 (0.65, 0.88)
 GED or high school 983 24 1.00 1.00
 Some college or associate degree 953 24 0.95 (0.86, 1.05) 0.93 (0.83, 1.04)
 Bachelor’s or advanced degree 184 16 0.54 (0.45, 0.65) 0.65 (0.53, 0.80)
Nicotine dependence
 Low 509 14 1.00 1.00
 Moderate 892 25 2.00 (1.78, 2.25) 1.81 (1.60, 2.05)
 High 1,068 28 2.26 (2.03, 2.51) 2.01 (1.79, 2.26)
Past quit attempts
 Have not tried to quit 835 22 1.10 (0.97, 1.25) 1.02 (0.87, 1.18)
 Tried cutting back 1,105 24 1.21 (1.07, 1.38) 1.21 (1.06, 1.39)
 Have tried to quit completely 529 20 1.00 1.00
Overall opinion of using tobacco
 Negative 937 21 1.00 1.00
 Neither negative nor positive 1,202 24 1.22 (1.09, 1.37) 1.25 (1.10, 1.42)
 Positive 330 23 1.20 (0.98, 1.47) 1.27 (1.02, 1.58)

Note, n’s and % of adult smokers across predictor categories who redeemed tobacco coupons when buying cigarettes in the past month.

Smokers with moderate (aOR 1.81, 95% CI 1.60, 2.05) and high (aOR 2.01, 95% CI 1.79, 2.26) tobacco dependence and those who had non-negative opinion of tobacco had significantly higher odds to redeem coupons when buying cigarette than smokers with low tobacco dependence and those who expressed negative view of tobacco use.

The intersection between race and gender in coupon receipt and redemption

All main effect models reported in Tables 23 were re-estimated to test for an interaction between gender and race in coupon receipt and redemption (Data not presented in Tables). There was no statistically significant gender × race interaction predicting email receipt. We found a statistically significant gender × race interaction in models predicting mail coupon receipt (P=0.032) and coupon redemption (P=0.013). We plotted statistically significant interactions using predicted probabilities produced by the margins command in Stata 13 (Fig. 1 in Appendix A). Both White and other race women had higher odds of receiving and redeeming tobacco coupons than Black women, however, the difference between men and women in mail coupon receipt and redemption was greatest in the other race group. Future research with adequate sample sizes of other race groups may further our understanding of these gender and racial differences.

The association between channel of coupon receipt and coupon redemption

Controlling for all demographic, economic, and smoking covariates, smokers who received coupons via mail only (aOR=2.97, 95% CI 2.31, 3.83), and those who received them via both channels (aOR=4.56, 95% CI 3.61, 5.76), had three time and nearly five times higher odds than those who received them via email only to redeem coupons when buying cigarettes (Table 4). Post hoc multiple comparisons using Bonferroni’s adjustment also show that smokers who receive coupons via both channels have higher odds to redeem coupons than those who receive them via mail only (aOR=1.53, 95% CI 1.24, 1.88).

Table 4.

Association between channel of coupon receipt and coupon redemption for cigarettes among U.S adult smokers who receive direct marketing coupons via email or mail PATH study (n=4,043), weighted estimates

Redemption of Tobacco Coupons
Independent variables Unadjusted Adjusted
n % OR (95% CI) aOR (95% CI)
Channel of coupon receipt
 Email 105 20 1.00 1.00
 Mail 691 42 3.24 (2.53, 4.15) 2.97 (2.31, 3.83)
 Email and Mail 984 53 4.94 (3.97, 6.15) 4.56 (3.61, 5.76)

Note. Adjusted model adjusts for all demographic, economic, and smoking variables;

n’s and % reflect adult smokers across predictor categories who has redeemed tobacco coupons when buying cigarettes in the past month.

DISCUSSION

In light of the tobacco industry’s continued efforts to push for tobacco product discounts and promotions, we sought to examine the prevalence and correlates of direct tobacco coupon receipt via two main marketing channels (email, mail) and of coupon redemption in the US population. Our findings confirm that receipt of direct marketing tobacco coupons is quite prevalent in the United States as over one-third of adult smokers reported receipt of such coupons. As the first study to report estimates of coupon receipt via specific direct marketing channels, we found that 22% and 32% of adult smokers receive tobacco coupons via email and mail channels, respectively. These estimates are consistent with data reported in previous studies showing that 35% to 49% of smokers receive direct marketing coupons (Choi et al., 2013; Choi et al., 2018a; Choi et al., 2018b; Lewis et al., 2004a), and are concerning given that smokers can obtain coupons through additional non-direct marketing channels (e.g., at point of sale). Our study is also the first national study to report coupon redemption estimates, and it expands previous state-level studies showing that nearly a fourth (22%) of smokers redeem coupons when purchasing cigarettes (Choi et al., 2013; Lewis et al., 2004a; Lewis et al., 2015; Xu et al., 2013). Taken together, these estimates translates into millions of US smokers being exposed to price promotions that lower their cigarette prices.

Demographic characteristics of smokers who receive direct marketing coupons have been reported in few empirical studies (Choi et al., 2013; Choi et al., 2018a; Xu et al., 2013), however, none has distinguished between email and mail channels of receipt. Consistent with these studies, we found that coupon receipt via both channels and coupon redemption are more prevalent among White, middle-aged 25-44 year old, female, and self-identified sexual minority smokers. The findings also show economic disparities with coupon receipt via both channels and coupon redemption being more significantly prevalent among smokers facing recent financial difficulties and those with middle levels of educational attainment ranging from GED to associate degree. It is notable that demographic groups with the highest odds of coupon receipt and redemption are also the groups with the highest cigarette smoking rates in the population (e.g., Middle-aged adults, non-Hispanics, sexual minority groups, and sexual minority females, GED to associate level education). Known as price sensitive groups, those segments of the smoker population are also more likely to use other price minimization strategies (e.g., switching to a less expensive brand; purchasing cigarettes in states with lower excise taxes; purchasing lower-priced cigarettes on the Internet, Indian reservations, and on the black market; rolling their own cigarettes; using price discounts such as multi-pack or cartons offers) as ways to save money on cigarettes (Choi et al., 2012; Xu et al., 2013). To that end, coupons and price promotions for cigarettes could play a role in sustaining existing sociodemographic disparities in cigarette consumption.

Although women in the US smoke at a lower rate compared to men, tobacco coupon receipt and redemption are significantly higher among women. This could be a function of the generally higher coupon consumption among women but could also be a result of the long history of targeting efforts by the tobacco industry. Tobacco industry internal documents reveal that tobacco companies have long viewed women as a major consumer base, and for over 4 decades, tobacco companies targeted specific subgroups of low socio-economic status (SES) women, including military wives, inner-city minority women, working women, and older women, with marketing efforts including offering price discounts by mail and at point of sale (Brown-Johnson et al., 2014). Paying closer attention to the intersection of gender and race/ethnicity, we found that both White and other race women are more likely to receive and redeem tobacco coupons than Black women, but the gender gap in this behavior between men and women is most pronounced among other minority race groups. Future research with adequate sample sizes of other race groups (Asians, American Indians \ Alaska Natives) may further our understanding of these gender and racial differences.

Accumulating evidence points to negative effects of tobacco coupons on smoking behavior of both adults and youth (Choi et al., 2019; Choi and Forster, 2014; Choi et al., 2018a; Rose et al., 2018; Soneji et al., 2014). Studies show that smokers who receive direct marketing coupons hold more positive views of the tobacco industry (Choi et al., 2013). Cross-sectional and longitudinal studies also show that use of tobacco coupons is associated with initiation and progression to smoking among adult non-smokers, and with sustained smoking and lower odds of cessation among adult smokers (Choi et al., 2019; Choi and Forster, 2014; Choi et al., 2018a; Rose et al., 2018; Soneji et al., 2014). Consistent with that, we found that more nicotine dependent smokers, who likely consume more cigarettes per day, and smokers with non-negative views of tobacco use are more likely to receive and redeem coupons than their counterparts. Of particular concern is the effect of coupon use on nicotine dependent smokers of low SES among which tobacco use remains disproportionately high (Jamal et al., 2015; United States Department of Health and Human Services et al., 2014). Coupons and price promotions targeted at them could lead to sustaining or widening the already large SES disparities in tobacco use and cessation (Campaign for Tobacco-Free Kids, 2015; Ham et al., 2011; Jamal et al., 2015; Siahpush et al., 2010; United States Department of Health and Human Services et al., 2014). Practitioners and policy makers should consider ways to incentivize low SES smokers to consider cessation as the default choice to saving money.

Our findings highlight the connection between direct coupon receipt and redemption. Receipt of coupons through mail or simultaneously through mail and email, increases the odds of coupon redemption when purchasing cigarettes. The strong association between mail coupon receipt and redemption was observed in a recent study showing that nearly 70% of smokers who receive tobacco direct mailings also use coupons to purchase cigarettes (Lewis et al., 2015). Whereas direct mail delivers paper coupons directly to the consumer’s address, direct email typically provides the consumer with a link through which they can claim coupons. The consumer is then required to log on to a company website, create an account, and choose to have tobacco coupons mailed to an address or downloaded through an application. In other words, receiving the actual coupons promoted via email require some extra effort on the consumer’s part. This may explain why coupon receipt via mail is more strongly associated with redemption than email receipt.

Effective tobacco control measures including increasing tobacco product prices and reducing targeted industry marketing and advertising, are policies that also reduce tobacco use disparities, particularly among low SES groups (Centers for Disease Control and Prevention, 2014b). Yet, coupon distribution and redemption remain unchallenged by policy in the vast majority of states. While the FSPTCA (United States Department of Health and Human Services, 2009) prohibits the sale of tobacco products through mail-order coupon redemption, it does not restrict the discounting of tobacco products via coupons (Tobacco Control Legal Consortium, 2011). The FSPTCA give states and local jurisdictions the authority to regulate tobacco product sales in their localities (Tobacco Control Legal Consortium, 2013). Whereas restricting coupon distribution is likely to face legal challenges related to Preemption, the Commerce Clause, and the industry’s right for commercial speech, prohibiting retailers from redeeming coupons at point of sale is a legally viable option that can be achieved through local laws (Tobacco Control Legal Consortium, 2011). In recent years, some states and local jurisdictions (e.g., New York city; Providence, Rhode Island; Massachusetts) have successfully implemented strong minimum price laws and local ordinances that prohibit the retail redemption of coupons (Tobacco Control Legal Consortium, 2013). Other States may follow suit to magnify the impact of price and tax increases on reducing tobacco use disparities. To prevent unintended consequences of such policies, however (e.g., use of lower-priced, unregulated, and illegally manufactured cigarettes) and to achieve health equity, policy-makers could improve accessibility to cessation services for populations affected by tobacco-related disparities (Centers for Disease Control and Prevention, 2014a), particularly low SES nicotine dependent smokers.

STRENGTHS AND LIMITATIONS

Data are nationally representative allowing generalizability of findings to the non-institutionalized U.S adult smoker population. The study has several limitations. Data were self-reported, thus a recall bias is possible if smokers fail to remember receiving coupons. In such a case, our estimates of coupon receipt are likely an underestimation of the real magnitude of this issue. Questions assessing coupon receipt did not assess the type of tobacco products promoted by these coupons. Previous studies, however, support that most tobacco coupons promote cigarette products (Brock et al., 2015; Choi and Forster, 2014). Questions on coupon receipt did not quantify exposures in terms of the number of coupons received or redeemed, or their economic value. Assessment of coupon redemption was not specific to coupons received via direct-to-consumer channels, and smokers may have redeemed coupons received through other channels (e.g., point of sale). In addition, PATH study did not assess coupon receipt of specific tobacco products other than cigarettes. The number of smokers who reported redemption of coupons for products other than cigarettes was too small to allow for meaningful statistical modeling. Finally, data on non-White minority racial groups other than Blacks (e.g., Asian, American Indians, Alaska Natives) are not available in PATH public use file (which was used to conduct all analyses) thus potential racial disparities concerning these groups could not be explored.

CONCLUSIONS

Our study offers new insights into the characteristics of the consumer base that receives and redeems tobacco industry coupons via direct marketing channels in the US. The findings point to demographic and socioeconomic disparities in coupon receipt and redemption, and highlight specific segments of the smoker population as vulnerable to industry direct marketing tactics. Receipt of coupons via direct to consumer marketing channels, particularly direct mail, are likely to translate into redemption of coupons when purchasing cigarettes. Restrictions on tobacco coupon redemption may incentivize smokers vulnerable to tobacco marketing tactics to quit, but should be implemented jointly with increasing access to affordable cessation resources.

Highlights.

  1. There are major demographic and economic disparities in receipt and use of tobacco coupons in the U.S.

  2. Coupon receipt and redemption are more prevalent in female, White, and sexual minority smokers.

  3. Coupon receipt and redemption are more prevalent in smokers with financial difficulties.

  4. Coupon receipt and redemption are more prevalent in nicotine dependent smokers.

  5. Redemption of coupons received via mail is higher than coupons received via email.

ACKNOWLEDGEMENTS AND FUNDING

Grant number P50CA180907 from the National Cancer Institute and the FDA Center for Tobacco Products (CTP) supported the first author’s time writing the research reported in this manuscript. Dr. Choi’s effort on this manuscript is supported by the National Institute on Minority Health and Health Disparities Division of Intramural Research. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH or the Food and Drug Administration.

Appendix A

Figure 1.

Figure 1.

Predicted probabilities, by gender and race, for (a) receipt of tobacco coupons via mail, (b) redemption of tobacco coupons when purchasing cigarettes. Wave 1 (2013-2014), the Population Assessment of Tobacco and Health (PATH) Study, United States.

Footnotes

Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

CONFLICTS OF INTEREST. None

References

  1. Brock B, Schillo BA, Moilanen M, 2015. Tobacco industry marketing: an analysis of direct mail coupons and giveaways. Tobacco control 24:505–08. [DOI] [PubMed] [Google Scholar]
  2. Brown-Johnson CG, England LJ, Glantz SA, Ling PM, 2014. Tobacco industry marketing to low socioeconomic status women in the USA. Tobacco control 23:e139–e46. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Campaign for Tobacco-Free Kids, 2015. Tobacco and Socioeconomic Status. Campaign for Tobacco-Free Kids, Washington, D.C. [Google Scholar]
  4. Cavazos-Rehg PA, Krauss MJ, Spitznagel EL, Chaloupka FJ, Luke DA, Waterman B, Grucza RA, Bierut LJ, 2014. Differential effects of cigarette price changes on adult smoking behaviors. Tobacco control 23:113–18. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Centers for Disease Control and Prevention, 2014a. Best Practices for Comprehensive Tobacco Control Programs, 2014. US Dept of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, Atlanta, GA. [Google Scholar]
  6. Centers for Disease Control and Prevention, 2014b. Best Practices User Guide: Health Equity in Tobacco Prevention and Control, Atlanta, GA. [Google Scholar]
  7. Chaloupka FJ, Straif K, Leon ME, 2011. Effectiveness of tax and price policies in tobacco control. Tobacco Control 20:235–38. [DOI] [PubMed] [Google Scholar]
  8. Choi K, Boyle RG, 2018. Changes in cigarette expenditure minimising strategies before and after a cigarette tax increase. Tobacco Control 27:99–104. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Choi K, Chen JC, Tan AS, Soneji S, Moran MB, 2019. Receipt of tobacco direct mail/email discount coupons and trajectories of cigarette smoking behaviours in a nationally representative longitudinal cohort of US adults. Tobacco Control 28:282–88. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Choi K, Forster JL, 2014. Frequency and characteristics associated with exposure to tobacco direct mail marketing and its prospective effect on smoking behaviors among young adults from the US Midwest. American journal of public health 104:2179–83. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Choi K, Hennrikus D, Forster J, St. Claire A, 2012. Use of Price-Minimizing Strategies by Smokers and Their Effects on Subsequent Smoking Behaviors. Nicotine & Tobacco Research 14:864–70. [DOI] [PubMed] [Google Scholar]
  12. Choi K, Hennrikus DJ, Forster JL, Moilanen M, 2013. Receipt and redemption of cigarette coupons, perceptions of cigarette companies and smoking cessation. Tobacco control 22:418–22. [DOI] [PubMed] [Google Scholar]
  13. Choi K, Soneji S, Tan AS, 2018a. Receipt of tobacco direct mail coupons and changes in smoking status in a nationally representative sample of US adults. Nicotine & Tobacco Research 20:1095–100. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Choi K, Taylor N, Forster J, 2018b. Sources and Number of Coupons for Cigarettes and Snus Received by a Cohort of Young Adults. American Journal of Health Promotion 32:153–60. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Czaplewski AJ, Olson EM, 2003. Adaptive strategies of tobacco firms subsequent to the 1998 Master Settlement Agreement: an examination of emergent tobacco promotional mix efforts. Social Marketing Quarterly 9:3–17. [Google Scholar]
  16. Federal Trade Commission, 2017. Cigarette Report for 2015. Federal Trade Commission, Washington, DC. . [Google Scholar]
  17. Gallus S, Schiaffino A, La Vecchia C, Townsend J, Fernandez E, 2006. Price and cigarette consumption in Europe. Tobacco Control 15:114–19. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Ham DC, Przybeck T, Strickland JR, Luke DA, Bierut LJ, Evanoff BA, 2011. Occupation and workplace policies predict smoking behaviors: analysis of national data from the current population survey. Journal of Occupational and Environmental Medicine 53:1337–45. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Hyland A, Bauer JE, Li Q, Abrams SM, Higbee C, Peppone L, Cummings KM, 2005. Higher cigarette prices influence cigarette purchase patterns. Tobacco Control 14:86–92. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Jamal A, Homa D, O’Connor E, Babb S, Caraballo R, Singh T, Hu S, King B, 2015. Current Cigarette Smoking Among Adults—United States, 2005-2014. Morbidity and Mortality Weekly Report 64:1233–40. [DOI] [PubMed] [Google Scholar]
  21. Jha P, Chaloupka FJ, 2000. The economics of global tobacco control. British Medical Journal 321:358–61. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Kress M, 2018. Philip Morris USA Launches Initiatives to Boost Combustible Segment, Convenience Store News.
  23. Lewis MJ, Delnevo CD, Slade J, 2004a. Tobacco industry direct mail marketing and participation by New Jersey adults. American Journal of Public Health 94:257–59. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Lewis MJ, Ling PM, 2016. “Gone are the days of mass-media marketing plans and short term customer relationships”: tobacco industry direct mail and database marketing strategies. Tobacco Control 25:430–36. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Lewis MJ, Manderski MTB, Delnevo CD, 2015. Tobacco industry direct mail receipt and coupon use among young adult smokers. Preventive Medicine 71:37–39. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Lewis MJ, Yulis SG, Delnevo C, Hrywna M, 2004b. Tobacco industry direct marketing after the Master Settlement Agreement. Health Promotion Practice 5:75S–83S. [DOI] [PubMed] [Google Scholar]
  27. Master Settlement Agreement, 1998.
  28. Rose SW, Glasser AM, Zhou Y, Cruz TB, Cohn AM, Lienemann BA, Byron MJ, Huang L-L, Meissner HI, et al. , 2018. Adolescent tobacco coupon receipt, vulnerability characteristics and subsequent tobacco use: analysis of PATH Study, Waves 1 and 2. Tobacco Control 27:e50–e56. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Seidenberg AB, Jo CL, 2017. Cigarette couponing goes mobile. Tobacco Control 26:233–34. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Siahpush M, Singh G, Jones P, Timsina L, 2010. Racial/ethnic and socioeconomic variations in duration of smoking: results from 2003, 2006 and 2007 Tobacco Use Supplement of the Current Population Survey. Journal of Public Health 32:210–18. [DOI] [PubMed] [Google Scholar]
  31. Soneji S, Ambrose BK, Lee W, Sargent J, Tanski S, 2014. Direct-to-consumer tobacco marketing and its association with tobacco use among adolescents and young adults. Journal of Adolescent Health 55:209–15. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Statacorp, 2013. Stata Statistical Software: Release 13. College Station, TX: Statacorp LP. [Google Scholar]
  33. Stevens VL, Diver WR, Stoklosa M, Flanders WD, Westmaas JL, Jemal A, Drope JM, Gapstur SM, Jacobs EJ, 2017. A Prospective Cohort Study of Cigarette Prices and Smoking Cessation in Older Smokers. Cancer Epidemiology and Prevention Biomarkers 26:1071–7. [DOI] [PubMed] [Google Scholar]
  34. Strong DR, Pearson J, Ehlke S, Kirchner T, Abrams D, Taylor K, Compton WM, Conway KP, Lambert E, et al. , 2017. Indicators of dependence for different types of tobacco product users: Descriptive findings from Wave 1 (2013–2014) of the Population Assessment of Tobacco and Health (PATH) study. Drug and Alcohol Dependence 178:257–66. [DOI] [PubMed] [Google Scholar]
  35. Tobacco Control Legal Consortium, 2011. Tobacco Coupon Regulations and Sampling Restrictions, Saint Paul, MN. [Google Scholar]
  36. Tobacco Control Legal Consortium, 2013. Policy Approaches to Restricting Tobaco Product Coupons and Retail Value-Added Promotions Saint Paul, MN. [Google Scholar]
  37. United States Department of Health and Human Services, 2009. The Family Smoking Prevention and Tobacco Control Act, Whashingon, DC. [Google Scholar]
  38. United States Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 2014. The Health Consequences of Smoking—50 Years of Progress: A Report of the Surgeon General, Atlanta, GA. [Google Scholar]
  39. United States Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, Food and Drug Administration, Center for Tobacco Products, 2017a. Population Assessment of Tobacco and Health (PATH) Study: Coodbook for Wave 1 Adult Data. Inter-university Consortium for Political and Social Research (ICPSR) [Google Scholar]
  40. United States Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, Food and Drug Administration, Center for Tobacco Products, 2017b. Population Assessment of Tobacco and Health (PATH) Study: User Guide. Inter-university Consortium for Political and Social Research (ICPSR) [Google Scholar]
  41. Xu X, Pesko MF, Tynan MA, Gerzoff RB, Malarcher AM, Pechacek TF, 2013. Cigarette Price-Minimization Strategies by U.S. Smokers. American Journal of Preventive Medicine 44:472–76. [DOI] [PMC free article] [PubMed] [Google Scholar]

RESOURCES