Table 4.
The concentrations of neuroleptic drugs and their metabolites in saliva samples (drug doses in mg/day used by patients are given in the parentheses).
| Saliva Sample | Concentration (ng/mL)/Dose (mg/day) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Aripiprazole | Dehydroaripiprazole | Carbamazepine | Carbamazepine-10,11-Epoxid | Clozapine | N-Desmethyl Clozapine | Olanzapine | N-Demethyl Olanzapine | Quetiapine | Norquetiapine | Risperidone | 9-OH-Risperidone | |
| 1 | 1051.52 (800) | 1534.39 | 21.32 (15) | 31.74 | 410.14 (700) | 25.66 | ||||||
| 2 | 85.82 (300) | 73.50 | 18.33 (3) | 57.68 | ||||||||
| 3 | 78.34 (20) | 17.17 | 317.00 (300) | 247.89 | 29.78 (6) | 50.57 | ||||||
| 4 | 19.02 (20) | 49.71 | 181.87 (600) | 285.91 | 29.10 (4) | 104.68 | ||||||
| 5 | 187.65 (400) | 35.36 | 21.09 (20) | 26.81 | 32.60 (300) | 12. | ||||||
| 6 | 68.23 (20) | 108.89 | 675.52 (200) | 34.26 | ||||||||
| 7 | 456.87 (800) | 134.21 | 172.11 (3) | 37.37 | ||||||||
| 8 | 18.55 (20) | 16.65 | 31.71 (150) | 12.97 | ||||||||
| 9 | 19.01 (15) | 15.53 | 24.39 (20) | 16.17 | ||||||||
| 10 | 11.48 (15) | 8.62 * | 26.02 (20) | 18.09 | ||||||||
| 11 | 46.68 (150) | 15.94 | ||||||||||
| 12 | 40.29 (150) | 20.94 | 74.55 (200) | 15.91 | 15.33 (6) | 78.16 | ||||||
| 13 | 30.35 (10) | 51.93 | 733.17 (700) | 371.44 | ||||||||
| 14 | 18.08 (20) | 24.94 | 51.86 (300) | 25.09 | ||||||||
| 15 | 77.93 (200) | 31.28 | ||||||||||
| 16 | 68.90 (100) | 28.85 | ||||||||||
| 17 | 10.91 (15) | 11.27 | 24.53 (20) | 34.00 | ||||||||
| 18 | 16.04 (15) | 13.07 | 24.40 (20) | 16.27 | ||||||||
| 19 | 930.97 (350) | 928.36 | 791.05 (300) | 200.01 | ||||||||
| 20 | 74.51 (50) | 50.56 | ||||||||||
| 21 | 132.51 (800) | 21.09 | 17.97 (15) | 15.94 | 54.54 (700) | 13.60 | ||||||
| 22 | 48.58 (300) | 29.16 | 14.43 (3) | 56.09 | ||||||||
| 23 | 83.62 (20) | 41.45 | 365.50 (300) | 281.07 | 49.03 (6) | 142.33 | ||||||
| 24 | 34.11 (20) | 19.50 | 83.21 (600) | 139.32 | 27.70 (4) | 23.87 | ||||||
| 25 | 155.27 (400) | 171.30 | 33.20 (20) | 49.15 | 131.30 (300) | 54.36 | ||||||
| 26 | 70.12 (20) | 113.71 | 55.07 (200) | 26.18 | ||||||||
| 27 | 68.87 (800) | 25.04 | 17.25 (3) | 57.81 | ||||||||
| 28 | 14.33 (15) | 17.97 | 18.68 (20) | 62.00 | ||||||||
| 29 | 13.49 (15) | 15.40 | 21.86 (20) | 16.40 | ||||||||
| 30 | 11.15 (15) | 8.11 * | 18.32 (20) | 17.36 | ||||||||
| 31 | 63.81 (150) | 16.25 | ||||||||||
| 32 | 69.63 (150) | 45.60 | 80.56 (200) | 22.79 | 17.05 (6) | 103.92 | ||||||
| 33 | 37.51 (10) | 16.68 | 440.16 (700) | 237.3 | ||||||||
| 34 | 17.92 (20) | 16.18 | 115.74 (300) | 15.87 | ||||||||
| 35 | 60.86 (200) | 14.70 | ||||||||||
| 36 | 29.21 (100) | 23.79 | ||||||||||
| 37 | 15.69 (15) | 10.11 | 21.54 (20) | 18.77 | ||||||||
| 38 | 11.50 (15) | 14.22 | 20.57 (20) | 16.17 | ||||||||
| 39 | 495.77 (350) | 274.28 | 226.35 (300) | 51.05 | ||||||||
| 40 | 51.25 (50) | 14.15 | ||||||||||
| Mean | 13.73 | 12.70 | 381.74 | 440.53 | 384.16 | 317.29 | 32.10 | 33.99 | 193.07 | 81.62 | 39.01 | 71.25 |
* The determined concentrations were below the concentrations for which the calibration curve was determined.